Del i serien Handbook of Experimental Pharmacology

Dopamine in the CNS I

Häftad, Engelska, 2012

739 kr

Beställningsvara. Skickas inom 10-15 vardagar. Fri frakt för medlemmar vid köp för minst 249 kr.

This double volume provides a systematic account of the anatomy, physiology, neurochemistry, molecular biology and behavioural pharmacology of dopamine in the central nervous system. HEP 154/I deals with the history of dopamine, the anatomy of dopamine neurons, the biochemistry and molecular biology of dopamine uptake sites and of dopamine receptors.

Produktinformation

Utgivningsdatum2012-10-30
Mått155 x 235 x 20 mm
Vikt557 g
FormatHäftad
SpråkEngelska
SerieHandbook of Experimental Pharmacology
Antal sidor344
FörlagSpringer-Verlag Berlin and Heidelberg GmbH & Co. KG
ISBN9783642627262

Tillhör följande kategorier

Biovetenskap inom Naturvetenskap och teknik
Biokemi inom Naturvetenskap och teknik
Cellbiologi inom Naturvetenskap och teknik
Farmakologi inom Medicin

1 Brain Dopamine: A Historical Perspective.- A. Introduction.- B. The First Half-Century: 1910–1959.- C. &“The Great Brain Serotonin-Catecholamine Debate”.- D. Striatal Dopamine, Parkinson‚s Disease and Dopamine Replacement.- E. Dopamine Pathways.- F. Experimental Models of Parkinson‚s Disease.- G. Dopamine Toxins.- H. Dopamine Uptake.- I. Physiology and Pathophysiology of Brain Dopamine.- J. Specific Dopamine Receptors.- K. Direct-Acting Dopamine Agonists.- L. Dopamine and Striatal Neurotransmitter Interactions.- M. Dopamine in Psychiatry.- N. Concluding Remark.- Abbreviations.- References.- 2 Birth of Dopamine: A Cinderella Saga.- A. Introduction.- B. Brodie‚s Breakthrough Discovery, Focusing on Serotonin.- C. Catecholamines Entering the Scene.- D. Discovery of Dopamine.- E. Facing Rejection by Leaders in the Field.- F. New Evidence for Monoaminergic Neurotransmission.- G. A Paradigm Shift: Chemical Transmission in the Brain and Emerging Synaptology.- H. &“Awakenings&”.- I. Mode of Action of Antipsychotic Agents.- J. Dopamine, the Reward System, and Drug Dependence.- K. Autoreceptors: Discovery and Therapeutic Implications.- L. Concluding Remarks.- References.- 3 The Place of the Dopamine Neurons Within the Organization of the Forebrain.- A. Introduction.- B. The Midbrain and Striatal Circuitry.- C. Connections Between the Midbrain and Cortex.- D. The Amygdala and Other Forebrain Projections.- E. Functional Modulation and Integration Through Dopamine Forebrain Pathways.- References.- 4 Synaptology of Dopamine Neurons.- A. Introduction.- B. Methods for Ultrastructural Labeling of DA Axons.- C. Regional Observations of DA Synaptology.- D. Discussion.- Abbreviations.- References.- 5 D1-Like Dopamine Receptors: Molecular Biology and Pharmacology.- A.Introduction.- B. Molecular Biology of D1-Like Receptors.- C. D1-Like Receptor Pharmacology.- D. Molecular Aspects of Functional Coupling and Signal Transduction for D1-Like Receptors.- E. Distribution of D1-Like Receptors.- F. Pharmacology of D1-Like Receptor-Mediated Function: Behaviour and D1-Like:D2-Like Interactions.- G. Are There Additional D1-Like Receptor Subtypes?.- H. Conclusions.- References.- 6 Understanding the Function of the Dopamine D2 Receptor: A Knockout Animal Approach.- A. Introduction.- B. Transcriptional Regulation of the Dopamine D2 Receptor.- C. Dopamine D2 Receptor Signal Transduction.- D. D2 Receptor Function In Vivo.- E. D2 Receptor‚s Role as an Autoreceptor.- F. D2 Receptor Signaling in Physiology.- G. Neuronal Protective Pathways via the D2 Receptor.- H. Antiproliferative Role of Dopamine in the Pituitary.- I. Genetic Association of the D2 Receptor with Disease.- J. Distinct Functions of the Dopamine D2 Receptor Isoforms.- K. Conclusion.- References.- 7 The Dopamine D3 Receptor and Its Implication in Neuropsychiatric Disorders and Their Treatments.- A. Introduction.- B. Intracellular Signaling of the D3 Receptor.- C. Pre- and Postsynaptic Localizations of the D3 Receptor in the Brain.- D. Coexisting D1 and D3 Receptors in Ventral Striatum Mediate Both Synergistic and Opposite Responses.- E. D1/D3 Receptor Interplay in the Induction and Expression of Behavioral Sensitization: Role of Brain-Derived Neurotrophic Factor.- F. D3 Receptor-Selective Pharmacological Agents.- G. The D3 Receptor and Schizophrenia.- H. The D3 Receptor and Drug Addiction.- I. The D3 Receptor and Depression.- J. Conclusions.- References.- 8 Dopamine D4 Receptors: Molecular Biology and Pharmacology.- A. The Dopamine D4 Receptor.- B. The Multiple Human D4 Receptors.- C.The D4 Receptor Involvement in Schizophrenia.- D. Conclusions.- References.- 9 Signal Transduction by Dopamine D1 Receptors.- A. Historical Perspective.- B. GTP-Binding Proteins Associated with D1-Family Receptors.- C. Adenylyl Cyclases and Phosphodiesterases in the Striatum.- D. cAMP-Dependent Protein Kinase.- E. cAMP-Activated Phosphorylation Pathways.- F. The Role of Protein Phosphatase 1 in the Action of D1 Receptors.- G. DARPP-32.- H. Other Actions of cAMP.- I. Concluding Remarks.- References.- 10 The Dopamine Transporter: Molecular Biology, Pharmacology and Genetics.- A. Introduction.- B. Molecular Biology.- C. Distribution of the Dopamine Transporter.- D. Pharmacology.- E. Genetics Related to the Dopamine Transporter.- Abbreviations.- References.- 11 Cellular Actions of Dopamine.- A. Introduction.- B. DA Receptor Expression in Neostriatal Neurons.- C. Dopaminergic Modulation of Intrinsic Properties of Neostriatal Neurons.- D. D1 Receptor Modulation of Synaptic Transmission and Repetitive Activity in Medium Spiny Neurons.- E. Modulation of Synaptic Transmission by D2-Like Receptors.- F. Dopaminergic Regulation of Corticostriatal Synaptic Plasticity.- G. Summary and Conclusions.- References.- 12 Dopamine and Gene Expression.- A. Introduction.- B. Dopamine Signaling to the Nucleus.- C. Acute Effects of Dopamine on Gene Expression.- D. Chronic Effects of Dopamine on Gene Expression.- References.

Du kanske också är intresserad av

Dopamine in the CNS II

Gaetano Di Chiara

Häftad, 2010

7 999 kr

Dopamine in the CNS

Shouyang Wang, Gaetano Di Chiara, Gaetano Di Chiara

Inbunden, 2002

1 169 kr

Dopamine in the CNS II

Gaetano Di Chiara, Michael Stix, Gaetano Di Chiara

Inbunden, 2002

7 999 kr

Akademiskt läsande och skrivande

Vendela Blomström, Jeanna Wennerberg

Häftad, 2026

469 kr

Kollegieblock 3 för 2

Kollegieblock A4 linjerat svart

Kollektion Stora A

39 kr

3 för 2 Frixion

Kulspetspenna Frixion Ball Clicker 0.7 svart, raderbar

Pilot

55 kr

Omvårdnadens grunder - paket

Sofia Almerud, Annica Backman, Anna-Karin Edberg, Anna Ehrenberg, My Engström, Katarina Göransson, Lena Marmstål Hammar, Stefan Nilsson, Lars Wallin, Helle Wijk, Joakim Öhlén, Lilas Ali, Anette Alvariza, Ann-Christine Andersson, Pia Andersson, Anna Anåker, Charlotta van Eggermont Arwidson, Margareta Asp, Åsa Audulv, Malin Axelsson, Mariette Bengtsson, Eva Benzein, Lena Berg, Monica Bergqvist, Eva-Karin Bergström, Ida Björkman, Catrin Björvell, Angela Bång, Carina Bååth, Josefin Bäckström, Karin Bölenius, David Edvardsson, Rakel Eklund, Inger Ekman, Mirjam Ekstedt, Ann Catrine Eldh, Karin Enskär, Sofia Erestam, Anneli Eriksson, Henrik Eriksson, Marie Ernsth Bravell, Jan Florin, Anna Forsberg, Henrietta Forsman, Anette Forss, Mio Fredriksson, Febe Friberg, Maria Grandahl, Tanja Gustafsson, Agneta Gånemo, Elizabeth Hanson, Malin Hansson, Amanda Hellström, Ingela Henoch, Inger Jansson, Maria Jirwe, Lena Johansson, Pauline Johansson, Unn-Britt Johansson, Birgitta Kerstis, Ann-Sofie Källberg, Ulrika Källman, Anita Kärner Köhler, Cecilia Larsdotter, Margret Lepp, Maria Lindström Nilsson, Mikael Lundmark, Anneli Löf, Lennart Magnusson, Catharina Melander, Jenny Milton, Beata Molin, Annika Nordin, Maria Norinder, Sepideh Olausson, Carina Persson, Kerstin Prignitz Sluys, Josefin Rahmqvist, Birgit Holritz Rasmussen, Anneli Ringblom, Karin C. Ringsberg, Ann Rudman, Ann-Marie Rydholm Hedman, Silje Rysst, Lars Sandman, Regina Santamäki Fischer, Britt-Inger Saveman, Johanna Sjömar, Karin Stenzelius, Anna Strömberg, Annelie J. Sundler, Märtha Sund Levander, Kristina Svantesson, Anna Swall, Susanne Syrén, Pia Tingström, Johanna Ulfvarson, Sara Wallström, Albert Westergren, Lena Wiklund Gustin, Ulrika Winblad