DNA Repair and Replication

Dr Roger J. A. Grand was an undergraduate in biochemistry at the University of Sheffield, followed by a PhD at the University of Leeds. After a fellowship at Royal Holloway College, University of London, he moved to the Department of Biochemistry at the University of Birmingham to study proteins involved in the regulation of striated muscle contraction. This research helped to define how signals were transmitted through the troponin complex to initiate muscle contraction. After a few years, Roger joined the Department of Cancer Sciences, which later became the Institute for Cancer and Genomic Sciences, at the University of Birmingham. Roger Grand, is now a Reader in Experimental Cancer Sciences, and leads a research group specialising in the study of various aspects of the DNA damage response, both in normal cells and in those undergoing viral infection. Most recently, his lab has been interested in rare inherited diseases linked to mutations in DNA repair proteins.Dr John J. Reynolds earned a degree in genetics and microbiology at the University of Sheffield followed by doctoral research at the Genome Damage and Stability Centre (University of Sussex), where he worked on characterising the molecular defects underlying rare human diseases caused by mutations in DNA single-strand break repair factors. His post-doctoral research at the Cancer and Genomic Sciences (University of Birmingham) has focused on identifying and characterising novel DNA damage response genes, and investigating how defects in DNA repair and DNA replication factors give rise to human diseases, such as microcephalic dwarfism.

• Preface Editors Contributors 1. Introduction John J. Reynolds, Roger J. A. Grand, and Martin R. Higgs2. DNA Replication and Cell Cycle Control Sara Priego Moreno, Rebecca M. Jones, and Agnieszka Gambus3. DNA Replication Termination and Genomic Instability Rebecca M. Jones, Sara Priego Moreno, and Agnieszka Gambus4. Mechanisms of DNA Damage Tolerance Cyrus Vaziri and Anastasia Zlatanou5. The Repair of DNA Single-Strand Breaks and DNA Adducts: Mechanisms and Links to Human Disease Alicja Winczura and John J. Reynolds6. Homologous Recombination at Replication Forks Eva Petermann7. Mechanism of Double-Strand Break Repair by Non-Homologous End Joining Michal Malewicz8. Protein Methylation and the DNA Damage Response Martin R. Higgs and Clare Davies9. Ubiquitin, SUMO and the DNA Double-Strand Break Response Ruth M. Densham, Alexander J. Garvin, and Joanna R. Morris10. Transcription in the Context of Genome Stability Maintenance Marco Saponaro11. RNA Binding Proteins and the DNA Damage Response Roger J. A. Grand12. DNA Replication and Inherited Human Disease John J. Reynolds and Grant S. Stewart13. Ataxia Telangiectasia and Ataxia Telangiectasia–Like Disorders A. Malcolm R. Taylor14. DNA Repair Mechanisms in Stem Cells and Implications during Ageing Rachel Bayley and Paloma Garcia15. Targeting Replication Stress in Sporadic Tumours Marwan Kwok and Tatjana Stankovic16. A Few of the Many Outstanding Questions John J. Reynolds and Roger J. A. GrandIndex