DNA Engineered Noble Metal Nanoparticles

Fundamentals and State-of-the-Art of Nanobiotechnology

Inbunden, Engelska, 2015

3 459 kr

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There is a growing interest in the use of nanoparticles modified with DNAs, viruses, peptides and proteins for the rational design of nanostructured functional materials and their use in biosensor applications. The challenge is to control the organization of biomolecules on nanoparticles while retaining their biological activity as potential chemical and gene therapeutics. These noble metal nanoparticles/biomolecules conjugates have specific properties and therefore they are attractive materials for nanotechnology in biochemistry and medicine.In this book, the author review work performed dealing with the DNA structure and functionalities, interactions between DNA, noble metal nanoparticles, surface active agents, solvents and other additives. Particular attention is given to how the DNA's chain length and the DNA conformation affect the interaction and structure of the nanoconjugates and nanostructures that are formed. Also discussed are the recent advances in the preparation, characterization, and applications of noble metal nanoparticles that are conjugated with DNA aptamers and oligomers. The advantages and disadvantages of functionalized nanoparticles through various detection modes are highlighted, including colorimetry, fluorescence, electrochemistry, SPR, and, mass spectrometry for the detection of small molecules and biomolecules. The functionalized noble metal nanoparticles are selective and sensitive for the analytes, showing their great potential in biosensing. Furthermore, this book reviews recent progress in the area of DNA-noble metal nanoparticles based artificial nanostructures, that is, the preparation, collective properties, and applications of various DNA-based nanostructures are also described.

Produktinformation

Utgivningsdatum2015-05-26
Mått163 x 241 x 37 mm
Vikt1 225 g
FormatInbunden
SpråkEngelska
SerieAdvanced Material Series
Antal sidor672
FörlagJohn Wiley & Sons Inc
ISBN9781118072141

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Teknik: allmänt inom Naturvetenskap och teknik

Acknowledgement ixPreface xi1 Introduction 12 Nucleic Acids 292.1 DNA/RNA Basics 292.2 Aptamers, Telomers and Oligonucleotides 502.3 Techniques and Approaches 632.4 DNA-Based Molecular Nanomachines 902.5 Peptide Nucleic Acid 1042.6 Nanobiotechnology 1123 Noble Metal Nanoparticles 1213.1 Preparation and Modification 1213.2 Optical and Physical Properties 1373.3 Conjugates 1444 DNA-Based Conjugates 1494.1 General 1494.2 Condensation 1524.3 Conjugates 1705 DNA-Noble Metal Nanoparticle Conjugates 1735.1 General Approaches 1735.2 DNA Monomers and Oligomers 1785.2.1 Gold Nanoparticles 1785.2.2 Silver Nanoparticles 2075.3 Hybridization and Denaturation 2245.4 DNA Biotemplates 2736 DNA-Gold Nanoparticle Conjugates 2816.1 DNA-Gold Zero-Dimensional Nanoparticle Conjugates 2816.2 DNA One-Dimensional Gold Nanoparticle Conjugates 2957 PNA-Noble Metal Nanoparticles Conjugates 3157.1 PNA-Gold Nanoparticle Conjugates 3157.2 PNA-Silver Nanoparticle Conjugates 3288 DNA-Silver Nanoparticles Conjugates 3359 The Structure of DNA-Noble Metal Nanoparticles Conjugates 3459.1 Configuration of DNA-Noble Metal Nanoparticles Conjugates 3459.2 Stabilization of DNA Conjugates 3589.3 Nanostructures and Nanoconstructs 3699.4 Colorimetric and Sensing Assays 38510 Photochemical and Photophysical Events 40310.1 Noble Metal Nanoparticles 40310.2 DNA Nucleobases 40610.3 DNA/PNA 41710.4 DNA-Dyes Conjugates 42910.5 DNA-AuNP-Dye Conjugates 44310.6 DNA-Gold Nanoparticle Conjugates 45510.7 DNA-AgNPs 46510.8 Hot Gold Nanoparticles 47511 Nanoparticle Therapeutics 48111.1 Biodecorated Nanoparticle-Based Therapies 48111.2 Photothermal Therapy 48911.3 Cells 49511.4 Gene Therapy 49911.5 Blood Fluid Effect 50511.6 Other Application Approaches 50712 Conclusion 515Nomenclature 533DNA Entities 545Vocabulary and Definitions 549References 564Index