Diversity and Functions of GABA Receptors: A Tribute to Hanns M�hler, Part A

Dr. Rudolph is Director of the Laboratory of Genetic Neuropharmacoloy at McLean Hospital and Professor of Psychiatry at Harvard Medical School. He studied medicine and completed a research thesis on G proteins at the Freie Universitat Berlin, Germany. After postdoctoral training at Baylor College of Medicine in Houston, Texas, where he developed a mouse model of inflammatory bowel disease and colon cancer, he moved to the Institute of Pharmacology and Toxicology of the University of Zurich to work on GABAA receptors. There, he developed different lines of knock-in mice in which diazepam-sensitive GABAA receptor subtypes were rendered insensitive to diazepam by a histidine to arginine point mutation. Studying these mice enables researchers to uncover unique functional roles of GABAA receptor subtypes. In 2005, he joined McLean Hospital in Belmont, MA, and Harvard Medical School, where his research group is elucidating the functions of GABAA receptor subtypes in defined neuronal populations.

• 1. The Legacy of the Benzodiazepine Receptor: From Flumazenil to Enhancing Cognition in Down Syndrome and Social Interaction in AutismHanns Möhler2. Behavioral Functions of GABAA  Receptor Subtypes – the Zurich ExperienceFlorence Crestani and Uwe Rudolph3. Allosteric Modulation of GABAA  Receptors via Multiple Drug Binding SitesWerner Sieghart4. Regulation of GABAARs by PhosphorylationYasuko Nakamura, Laura M. Darnieder, Tarek Z. Deeb and Stephen J. Moss5. EndozepinesZoya Farzampour, Richard J. Reimer and John Huguenard6. Inhibitory Neurosteroids and the GABAA  ReceptorSandra Seljeset, Duncan Laverty and Trevor G Smart7. Interactions of Flavonoids with Ionotropic GABAA  ReceptorsJane R Hanrahan, Mary Chebib and Graham A R Johnston8. GABAA  Receptor Partial Agonists and Antagonists: Structure, Binding Mode, and PharmacologyJacob Krall, Thomas Balle, Niels Krogsgaard-Larsen, Troels E. Sørensen, Povl Krogsgaard-Larsen, Uffe Kristiansen and Bente Frølund9. Closing the Gap between the Molecular and Systemic Actions of Anesthetic AgentsBernd Antkowiak

Praise for the Series: "...recommended not only to pharmacologists but also to all those in related disciplines" --Nature