Direct Nose-to-Brain Drug Delivery

Dr. Chandrakantsing Pardeshi holds PhD degree in Pharmaceutical Sciences from Kavayitri Bahinabai Chaudhari North Maharashtra University (KBC NMU, India). Presently, he is an Associate Professor of Pharmaceutics at R. C. Patel Institute of Pharmaceutical Education and Research (Shirpur, India) where he is inventing the novel devices for direct nose-to-brain drug delivery. Dr. Pardeshi has authored more than 50 peer-reviewed publications, 21 book chapters and several research abstracts. He has, to his credit, 2 Indian patents and 1 research project funded by University Grants Commission (New Delhi, India). He is an active referee and editorial board member of few reputed multidisciplinary international journals. Dr. Pardeshi also contributed as a Grant evaluator in Government Funding bodies. He has been awarded with Gold Medal from KBC NMU (India), and Excellence Award from Indian Drug Manufacturer’s Association (IDMA, India). Eliana B. Souto is Habil. Professor from the Department of Pharmaceutical Technology of the Faculty of Pharmacy of University of Porto. Prof. Souto graduated in Pharmaceutical Sciences from University of Coimbra (2000), is holder of a master’s in science degree in Pharmaceutical Technology from University of Porto (2002), and PhD in Pharmaceutical Nanotechnology and Biopharmaceutics from the Institut fuer Pharmazie der Freie Universitaet Berlin, Germany (2005). Her research lines include the design, development, and characterization of new drug delivery systems to overcome biological barriers. Prof. Souto serves as Associate Editor, member of the Editorial Board, and Reviewer of several international scientific journals and has published more than 500 works (original and review papers, books and book chapters) in the field of nanosciences and nanomedicine. Prof. Souto also acts as independent expert for several national, European and international funding agencies, and as consultant for pharmaceutical industry.

• Section I Basic considerations in nose-to-brain drug delivery1. An overview of anatomical and physiological aspects of the nose and the brainDignesh Khunt and Manju Misra2. Direct transport theory: From the nose to the brainNamdev Dhas, Dattatray Yadav, Ashutosh Singh, Atul Garkal, Ritu Kudarha, Priyanka Bangar, Jignasa Savjani, Chandrakantsing V. Pardeshi, Neha Garg, and Tejal Mehta3. Physicochemical, biopharmaceutical, and practical considerations for efficient nose-to-brain drug deliveryUmesh D. Laddha and Amol A. TagalpallewarSection II Nanotechnology and naso-brain drug delivery4. Nanomedicines for CNS therapy: Fundamental aspectsDrashti Desai, Bala Prabhakar, and Pravin Shende5. Nanotechnological advances in direct nose-to-brain drug delivery for neurodegenerative disorders and other neuroailments Rahul Shukla, Ashish Kumar, and S.J.S. Flora6. Surface modification of nanocarriers as a strategy to enhance the direct nose-to-brain drug delivery Chandrakantsing V. Pardeshi and Eliana B. Souto7. Mucoadhesion as a strategy to enhance the direct nose-to-brain drug deliveryMrunal Patil8. Nanoparticles for direct nose-to-brain drug delivery: Implications of targeting approachesRaju O. Sonawane, Yogeshwar Bachhav, Avinash R. Tekade, and Chandrakantsing V. Pardeshi9. Strategies for enhanced direct nose-to-brain drug deliveryYamini Madav and Sarika WairkarSection III Carriers for direct nose-to-brain drug delivery10. Particulate carriers for nose-to-brain deliveryShiv Bahadur and Kamla Pathak11. Vesicular carriers for direct nose-to-brain drug deliveryPrashant K. Deshmukh, Swapnil N. Jain, Pravin O. Patil, and Chandrakantsing V. Pardeshi12. Gel-based delivery of neurotherapeutics via naso-brain pathwaysHitendra S. Mahajan and Payal H. PatilSection IV Applications of direct nose-to-brain delivery13. Applications of direct nose-to-brain drug delivery in medicine and pharmacyGanesh B. Shevalkar, Mahendra K. Prajapati, Rohan V. Pai, and Kamlesh D. Mali14. Applications of direct nose-to-brain drug delivery in biomedicine, biotechnology, tissue engineering, and immunologySanjay B. Patil15. Diagnostic and theranostic intranasal nanointerventions for brain diseasesPrashant Upadhaya, Sreeranjini Pulakkat, and Vandana Patravale16. Nose-to-brain delivery of biologics and stem cellsMukta Agrawal, Aditya Narayan Konwar, Amit Alexander, and Vivek Borse17. Applications of nose-to-brain delivery in nanodiagnosis and nanotherapy of neurodegenerative disordersAbhijeet Kulkarni, Mahesh Shinde, Gaurav Sonawane, Hitesh Raotole, Rohit Pande, and Chandrakantsing V. Pardeshi18. Intranasal gene therapy for the treatment of neurological disordersNamdev Dhas, Tejal Mehta, Shilpa Sharma, Atul Garkal, Dattatray Yadav, Kartik Hariharan, Babeeta Shamjetshabam, Shubham Khot, Ritu Kudarha, Priyanka Bangar, Gajanan Arbade, and Pratap Kalyankar19. Potential of naso-brain drug delivery in glioblastoma therapyAmarjitsing Rajput, Nikunj Tandel, Swapnil Borse, and Shital Butani20. Nose-to-brain delivery of antiretroviral drugs against NeuroAIDSKailas K. Moravkar, Devanshi S. Shah, Durgesh K. Jha, Purnima D. Amin, and Sanjay J. SuranaSection V Technological advances for effective drug administration21. A technology overview on advanced drug administration devices for effective nose-to-brain deliverySadhana R. Shahi and Chandrakantsing V. PardeshiSection VI Evaluation of direct nose-to-brain drug delivery22. Experimental models for evaluation of direct nose-to-brain drug deliveryVinit V. Agnihotri, Ashish P. Gorle, Chandrakantsing V. Pardeshi, and Sanjay J. Surana23. Quantitative and qualitative analysis of direct nose-to-brain drug deliveryVeena S. Belgamwar, Vidyadevi T. Bhoyar, Sagar Trivedi, and Chandrakantsing V. PardeshiSection VII Toxicity and regulatory aspects24. Toxicity aspects: Crucial obstacles to clinical translation of nanomedicinesVikas Bansal, Sameer S. Katiyar, and Chander Parkash Dora25. Nose-to-brain drug delivery: Regulatory aspects, clinical trials, patents, and future perspectivesAbhijeet Pandey, Ajinkya Nikam, Shreya Basavraj, Sadhana Mutalik, Divya Gopalan, Sanjay Kulkarni, Bharat Padya, Gasper Fernandes, and Srinivas Mutalik