Michael D. Lockshin, MD, MACRDirector, Barbara Volcker CenterHospital for Special SurgeryProfessor of Medicine and Obstetrics GynecologyWeill Cornell MedicineNew York, NYMary K. Crow, MDPhysician-in-ChiefChair, Department of MedicineBenjamin M. Rosen Chair in Immunology and Inflammation ResearchHospital for Special SurgeryChief, Division of RheumatologyJoseph P. Routh Professor of Rheumatic Diseases in MedicineWeill Cornell MedicineNew York, NYMedha Barbhaiya, MD, MPHAssistant Attending PhysicianBarbara Volcker Center for Women and Rheumatic DiseaseHospital for Special SurgeryAssistant Professor of MedicineWeill Cornell MedicineNew York, NY

• ​Part I - What is a diagnosis.- 1. Chasing My Cure: Lessons learned from my rare illness.- 2. A Pragmatic Approach to Diagnostic Categorization.- 3. How diagnoses are assigned.- 4. Toward Molecular Diagnoses for Autoimmune Rheumatic Diseases.- Part II - Purposes of diagnosis.- 5. Diagnostic Uncertainty in Drug Development.- 6. Confronting the Inevitability of Diagnostic Uncertainty Across Multiple Legal Domains.- 7. The FDA and the Drug Development Process.- Part III - Assigning diagnoses.- 8. Diagnosis of Systemic Lupus Erythematosus in the Age of Precision Medicine.- 9. The Impact of Antinuclear Antibody Testing on the Naming and Misnaming of Disease.- 10. In the Box or Out of the Box.- 11. Ever Evolving Disease Classification Criteria for Clinical Trials and Studies: The Case of Systemic Lupus Erythematosus.- 12. Prognosis: A framework for clinical practice when patients have ‘symptoms with no diagnosis’.- 13. When the Illness Has No Name: Focus on ClinicalTrials in Systemic Lupus Erythematosus.- 14. The Epidemiology of Systemic Lupus Erythematosus.- Part IV - Uncertainty.- 15. Managing and tolerating diagnostic uncertainty.- 16. Is there a textbook for non-textbook patients?.- 17. The Changing Role Of Uncertainty In Physician-Patient Relationships.- 18. Syndromes in Search of a Name: Disorders of Consciousness, Neuroethics & Nosological Humility.- 19. Reflections on the Conference by a Physician-Patient.- 20. Clinical Ambiguity in the Intelligent Machine Era (Treats Breaks and Discharges).- 21. Shame, Name, Give Up the Game? Three Approaches to Uncertainty.

Michael D. Lockshin, MD, MACRDirector, Barbara Volcker CenterHospital for Special SurgeryProfessor of Medicine and Obstetrics GynecologyWeill Cornell MedicineNew York, NYMary K. Crow, MDPhysician-in-ChiefChair, Department of MedicineBenjamin M. Rosen Chair in Immunology and Inflammation ResearchHospital for Special SurgeryChief, Division of RheumatologyJoseph P. Routh Professor of Rheumatic Diseases in MedicineWeill Cornell MedicineNew York, NYMedha Barbhaiya, MD, MPHAssistant Attending PhysicianBarbara Volcker Center for Women and Rheumatic DiseaseHospital for Special SurgeryAssistant Professor of MedicineWeill Cornell MedicineNew York, NY

• ​Part I - What is a diagnosis.- 1. Chasing My Cure: Lessons learned from my rare illness.- 2. A Pragmatic Approach to Diagnostic Categorization.- 3. How diagnoses are assigned.- 4. Toward Molecular Diagnoses for Autoimmune Rheumatic Diseases.- Part II - Purposes of diagnosis.- 5. Diagnostic Uncertainty in Drug Development.- 6. Confronting the Inevitability of Diagnostic Uncertainty Across Multiple Legal Domains.- 7. The FDA and the Drug Development Process.- Part III - Assigning diagnoses.- 8. Diagnosis of Systemic Lupus Erythematosus in the Age of Precision Medicine.- 9. The Impact of Antinuclear Antibody Testing on the Naming and Misnaming of Disease.- 10. In the Box or Out of the Box.- 11. Ever Evolving Disease Classification Criteria for Clinical Trials and Studies: The Case of Systemic Lupus Erythematosus.- 12. Prognosis: A framework for clinical practice when patients have ‘symptoms with no diagnosis’.- 13. When the Illness Has No Name: Focus on ClinicalTrials in Systemic Lupus Erythematosus.- 14. The Epidemiology of Systemic Lupus Erythematosus.- Part IV - Uncertainty.- 15. Managing and tolerating diagnostic uncertainty.- 16. Is there a textbook for non-textbook patients?.- 17. The Changing Role Of Uncertainty In Physician-Patient Relationships.- 18. Syndromes in Search of a Name: Disorders of Consciousness, Neuroethics & Nosological Humility.- 19. Reflections on the Conference by a Physician-Patient.- 20. Clinical Ambiguity in the Intelligent Machine Era (Treats Breaks and Discharges).- 21. Shame, Name, Give Up the Game? Three Approaches to Uncertainty.

Michael D. Lockshin, MD, MACRDirector, Barbara Volcker CenterHospital for Special SurgeryProfessor of Medicine and Obstetrics GynecologyWeill Cornell MedicineNew York, NYMary K. Crow, MDPhysician-in-ChiefChair, Department of MedicineBenjamin M. Rosen Chair in Immunology and Inflammation ResearchHospital for Special SurgeryChief, Division of RheumatologyJoseph P. Routh Professor of Rheumatic Diseases in MedicineWeill Cornell MedicineNew York, NYMedha Barbhaiya, MD, MPHAssistant Attending PhysicianBarbara Volcker Center for Women and Rheumatic DiseaseHospital for Special SurgeryAssistant Professor of MedicineWeill Cornell MedicineNew York, NY

• ​Part I - What is a diagnosis.- 1. Chasing My Cure: Lessons learned from my rare illness.- 2. A Pragmatic Approach to Diagnostic Categorization.- 3. How diagnoses are assigned.- 4. Toward Molecular Diagnoses for Autoimmune Rheumatic Diseases.- Part II - Purposes of diagnosis.- 5. Diagnostic Uncertainty in Drug Development.- 6. Confronting the Inevitability of Diagnostic Uncertainty Across Multiple Legal Domains.- 7. The FDA and the Drug Development Process.- Part III - Assigning diagnoses.- 8. Diagnosis of Systemic Lupus Erythematosus in the Age of Precision Medicine.- 9. The Impact of Antinuclear Antibody Testing on the Naming and Misnaming of Disease.- 10. In the Box or Out of the Box.- 11. Ever Evolving Disease Classification Criteria for Clinical Trials and Studies: The Case of Systemic Lupus Erythematosus.- 12. Prognosis: A framework for clinical practice when patients have ‘symptoms with no diagnosis’.- 13. When the Illness Has No Name: Focus on ClinicalTrials in Systemic Lupus Erythematosus.- 14. The Epidemiology of Systemic Lupus Erythematosus.- Part IV - Uncertainty.- 15. Managing and tolerating diagnostic uncertainty.- 16. Is there a textbook for non-textbook patients?.- 17. The Changing Role Of Uncertainty In Physician-Patient Relationships.- 18. Syndromes in Search of a Name: Disorders of Consciousness, Neuroethics & Nosological Humility.- 19. Reflections on the Conference by a Physician-Patient.- 20. Clinical Ambiguity in the Intelligent Machine Era (Treats Breaks and Discharges).- 21. Shame, Name, Give Up the Game? Three Approaches to Uncertainty.