This book provides a comprehensive overview of diabetic wounds, focusing on the dual challenges of impaired healing and antimicrobial resistance. It explores wound pathophysiology, microbial biofilms, treatment limitations, and emerging therapeutic strategies, including nanotechnology, peptides, natural products, and computational approaches. Special attention is given to multidrug-resistant organisms in diabetic wound infections and their impact on patient outcomes. The book critically examines current therapies and proposes innovative, multidisciplinary approaches to diagnosis, prevention, and treatment. Bringing together perspectives from pharmacology, microbiology, nanotechnology, and clinical sciences, it bridges fundamental research and translational applications. It is a valuable resource for researchers, clinicians, graduate students, and industry professionals working in diabetic wound management.