Gunter Wolf is Professor and Chairman, Department for Internal Medicine III (Nephrology, Rheumatology, Osteology, Endocrinology and Diabetology) at the Friedrich Schiller University in Jena, Germany. Professor Wolf is well known both in Europe and America, and is involved in many editorial boards and journals such as Kidney International, Journal American Society of Nephrology, European Journal of Clinical Investigation, Hypertension and the renal section of the American Journal of Physiology. Professor Wolf is also the author of Obesity and the Kidney, Karger, 2006.

• Contributors viiPreface xPart I Introduction and Pathophysiology1 History of diabetic nephropathy: a personal account 3Eberhard Ritz2 Epidemiology of chronic kidney disease in diabetes 14Andrea Icks and Michael Koch3 Genetic risk factors for diabetic nephropathy 29Carsten A. Böger and Peter R. Mertens4 Pathophysiology of diabetic nephropathy 45Ivonne Loeffler5 Histology of human diabetic nephropathy 62Kerstin Amann and Christoph Daniel6 Natural history and diagnosis of diabetic kidney disease 70Bethany Karl and Kumar SharmaPart II Special Situations, Risk Factors and Complications7 Cardiovascular disease in diabetic nephropathy: pathophysiology and treatment 85Martin Busch8 Statin therapy in patients with diabetic nephropathy 101Christoph Wanner9 Diabetes mellitus bone and kidney 116Thomas Neumann and Gabriele Lehmann10 Diabetes pregnancy and the kidney 129Helmut Kleinwechter and Ute Schäfer-Graf11 Diabetic nephropathy in children 143Kai D Nüsken and Jörg Dötsch12 Diabetes the kidney and retinopathy 153Hans-Peter HammesPart III Prevention and Therapy13 Reducing progression of diabetic nephropathy by antihyperglycemic treatment 171Christoph Hasslacher14 Dosage of antihyperglycemic drugs in patients with renal insufficiency 186Alexander Sämann and Ulrich A. Müller15 Reducing progression of diabetic nephropathy by antihypertensive treatment 202Anita Hansen, Ivo Quack and Lars Christian Rump16 Treatment of the patient with end-stage diabetic nephropathy 215Muriel Ghosn and Fuad N. Ziyadeh17 Combined pancreas and kidney transplantation or kidney alone transplantation for patients with diabetic nephropathy 232Hermann J. Kissler, Christiane Rüster and Utz SettmacherIndex 253Color plate section can be found facing page 54

“It should therefore be essential reading for diabetes/endocrine and renal speciality trainees.  It will also appeal to both the general practitioner and those looking after acutely ill patients.”  (Diabetes Update, 1 July 2013)

Gunter Wolf is Professor and Chairman, Department for Internal Medicine III (Nephrology, Rheumatology, Osteology, Endocrinology and Diabetology) at the Friedrich Schiller University in Jena, Germany. Professor Wolf is well known both in Europe and America, and is involved in many editorial boards and journals such as Kidney International, Journal American Society of Nephrology, European Journal of Clinical Investigation, Hypertension and the renal section of the American Journal of Physiology. Professor Wolf is also the author of Obesity and the Kidney, Karger, 2006.

• Contributors viiPreface xPart I Introduction and Pathophysiology1 History of diabetic nephropathy: a personal account 3Eberhard Ritz2 Epidemiology of chronic kidney disease in diabetes 14Andrea Icks and Michael Koch3 Genetic risk factors for diabetic nephropathy 29Carsten A. Böger and Peter R. Mertens4 Pathophysiology of diabetic nephropathy 45Ivonne Loeffler5 Histology of human diabetic nephropathy 62Kerstin Amann and Christoph Daniel6 Natural history and diagnosis of diabetic kidney disease 70Bethany Karl and Kumar SharmaPart II Special Situations, Risk Factors and Complications7 Cardiovascular disease in diabetic nephropathy: pathophysiology and treatment 85Martin Busch8 Statin therapy in patients with diabetic nephropathy 101Christoph Wanner9 Diabetes mellitus bone and kidney 116Thomas Neumann and Gabriele Lehmann10 Diabetes pregnancy and the kidney 129Helmut Kleinwechter and Ute Schäfer-Graf11 Diabetic nephropathy in children 143Kai D Nüsken and Jörg Dötsch12 Diabetes the kidney and retinopathy 153Hans-Peter HammesPart III Prevention and Therapy13 Reducing progression of diabetic nephropathy by antihyperglycemic treatment 171Christoph Hasslacher14 Dosage of antihyperglycemic drugs in patients with renal insufficiency 186Alexander Sämann and Ulrich A. Müller15 Reducing progression of diabetic nephropathy by antihypertensive treatment 202Anita Hansen, Ivo Quack and Lars Christian Rump16 Treatment of the patient with end-stage diabetic nephropathy 215Muriel Ghosn and Fuad N. Ziyadeh17 Combined pancreas and kidney transplantation or kidney alone transplantation for patients with diabetic nephropathy 232Hermann J. Kissler, Christiane Rüster and Utz SettmacherIndex 253Color plate section can be found facing page 54

“It should therefore be essential reading for diabetes/endocrine and renal speciality trainees.  It will also appeal to both the general practitioner and those looking after acutely ill patients.”  (Diabetes Update, 1 July 2013)

Gunter Wolf is Professor and Chairman, Department for Internal Medicine III (Nephrology, Rheumatology, Osteology, Endocrinology and Diabetology) at the Friedrich Schiller University in Jena, Germany. Professor Wolf is well known both in Europe and America, and is involved in many editorial boards and journals such as Kidney International, Journal American Society of Nephrology, European Journal of Clinical Investigation, Hypertension and the renal section of the American Journal of Physiology. Professor Wolf is also the author of Obesity and the Kidney, Karger, 2006.

• Contributors viiPreface xPart I Introduction and Pathophysiology1 History of diabetic nephropathy: a personal account 3Eberhard Ritz2 Epidemiology of chronic kidney disease in diabetes 14Andrea Icks and Michael Koch3 Genetic risk factors for diabetic nephropathy 29Carsten A. Böger and Peter R. Mertens4 Pathophysiology of diabetic nephropathy 45Ivonne Loeffler5 Histology of human diabetic nephropathy 62Kerstin Amann and Christoph Daniel6 Natural history and diagnosis of diabetic kidney disease 70Bethany Karl and Kumar SharmaPart II Special Situations, Risk Factors and Complications7 Cardiovascular disease in diabetic nephropathy: pathophysiology and treatment 85Martin Busch8 Statin therapy in patients with diabetic nephropathy 101Christoph Wanner9 Diabetes mellitus bone and kidney 116Thomas Neumann and Gabriele Lehmann10 Diabetes pregnancy and the kidney 129Helmut Kleinwechter and Ute Schäfer-Graf11 Diabetic nephropathy in children 143Kai D Nüsken and Jörg Dötsch12 Diabetes the kidney and retinopathy 153Hans-Peter HammesPart III Prevention and Therapy13 Reducing progression of diabetic nephropathy by antihyperglycemic treatment 171Christoph Hasslacher14 Dosage of antihyperglycemic drugs in patients with renal insufficiency 186Alexander Sämann and Ulrich A. Müller15 Reducing progression of diabetic nephropathy by antihypertensive treatment 202Anita Hansen, Ivo Quack and Lars Christian Rump16 Treatment of the patient with end-stage diabetic nephropathy 215Muriel Ghosn and Fuad N. Ziyadeh17 Combined pancreas and kidney transplantation or kidney alone transplantation for patients with diabetic nephropathy 232Hermann J. Kissler, Christiane Rüster and Utz SettmacherIndex 253Color plate section can be found facing page 54

“It should therefore be essential reading for diabetes/endocrine and renal speciality trainees.  It will also appeal to both the general practitioner and those looking after acutely ill patients.”  (Diabetes Update, 1 July 2013)