Michael T. Johnstone, MD, and Aristidis Veves, MD, DSc, have comprehensively their classic reference that reviews both the clinical and scientific aspects of diabetic cardiovascular disease. The contributors thoroughly discuss the mechanisms and risk factors of diabetes in relation to hypertension, dyslipidemia, thrombosis, atherosclerosis, coronary artery disease, and congestive heart failure. Their review includes a full examination of the epidemiology, mechanisms, methods of assessment, and treatment of the disease at the macrovascular level, and a discussion of the microvascular effects, including retinopathy, nephropathy, neuropathy, and compromised microcirculation in the diabetic foot.

• Pathophysiology.- Effects of Insulin on the Vascular System.- Effects of Diabetes and Insulin Resistance on Endothelial Functions.- Diabetes and Advanced Glycoxidation End-Products.- The Renin—Angiotensin System in Diabetic Cardiovascular Complications.- PPARs and Their Emerging Role in Vascular Biology, Inflammation, and Atherosclerosis.- Diabetes and Thrombosis.- Role of Estrogens in Vascular Disease in Diabetes.- Poly(ADP-Ribose) Polymerase Activation and Nitrosative Stress in the Development of Cardiovascular Disease in Diabetes.- Adiponectin and the Cardiovascular System.- Nitric Oxide and Its Role in Diabetes Mellitus.- Diabetes and Atherosclerosis.- The Use of Animal Models to Study Diabetes and Atherosclerosis and Potential Anti-Atherosclerotic Therapies.- Clinical.- The Metabolic Syndrome and Vascular Disease.- Diabetes and Hypertension.- Diabetes and Dyslipidemia.- Diabetic Retinopathy.- Diabetic Nephropathy.- Diabetic Neuropathy.- Microcirculation of the Diabetic Foot.- Epidemiology of Peripheral Vascular Disease.- Noninvasive Methods to Assess Vascular Function and Pathophysiology.- Peripheral Vascular Disease in Patients With Diabetes Mellitus.- Therapeutic Interventions to Improve Endothelial Function in Diabetes.- Preoperative Assessment and Perioperative Management of the Surgical Patient With Diabetes Mellitus.- Diabetes and Percutaneous Interventional Therapy.- Cardiac Surgery and Diabetes Mellitus.- Heart Failure and Cardiac Dysfunction in Diabetes.- Diabetes Mellitus and Heart Disease.

Reviews of the Second Edition "...provides a great resource for readers needing to learn more about the relationship between these disease entities. The book is recommended for any series student of diabetes. In particular, cardiologists and cardiology fellows, as well as cardiovascular surgeons and fellows, should be familiar with the material in it. It is also a valuable resource for those with more advanced knowledge of diabetes, such as endocrinologists and researchers active in the field of diabetes and cardiovascular diseases." -The New England Journal of Medicine "This second edition is a timely work by many eminent contributors. It summarizes the vast knowledge about diabetes mellitus and cardiovascular disease into one volume." - Doody's Health Sciences Book Review Journal From Reviews of the First Edition... "All practicing clinicians would find some value in this text, but especially cardiologists and internal medicine practitioners as well as vascular specialists. Family medicine physicians and medical students would find it a good reference...This is indeed a comprehensive review of the vascular implications of diabetes. It is an important book because of the increasing prevalence of diabetes in our society. The book provides a good starting point for researchers since one can be struck after reading it that there are many opportunities for investigation presented here. It is a worthwhile addition to the medical literature. "-Doody's Health Sciences Book Review Journal "...covers the range of problems, both clinical and biochemical, that arise in the cardiovascular system of those with diabetes. I highly recommend the book to interested medical students and residents and all clinicians who work with patients with diabetes." - Canadian Family Physician "...could serve as a clinical textbook as well as a source and stimulus for further research in the field of diabetes associated cardiovascular disease. It addresses the needs of general physicians, specialists and medical students." -Diabetologia "...particularly timely...fills a need in the scientific literature that is only now beginning to be appreciated." -Preventive Cardiology "...highly recommended to clinicians as well as to researchers interested in diabetes." -Acta Cardiologica "...a comprehensive review of the vascular implications of diabetes...a worthwhile addition to the medical literature." -Doody's Health Sciences Book Review Journal "...could serve as a clinical textbook as well as a source and stimulus for further research in the field of diabetes associated cardiovascular disease. It addresses the needs of general physicians, specialists and medical students." -Diabetologia