Developmental Toxicology

Methods and Protocols

Häftad, Engelska, 2016

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The discipline of developmental toxicology is an integration of concepts, models, and methodologies based heavily on the superimposition of toxicology principles upon the science of developmental biology.

Produktinformation

Utgivningsdatum2016-08-23
Mått178 x 254 x undefined mm
FormatHäftad
SpråkEngelska
SerieMethods in Molecular Biology
Antal sidor471
FörlagHumana Press Inc.
ISBN9781493962075

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Farmakologi inom Medicin

Volume Overview - Introduction.-In Vivo Models of Developmental Toxicology.-Caenorhabditis Elegans as a Model in Developmental Toxicology.-Zebrafish Embryo Developmental Toxicology Assay.-Gene Knockdown by Morpholino-modified Oligonucleotides in the Zebrafish (Danio rerio) Model: Applications for Developmental Toxicology.-An Amphibian Model for Studies of Developmental Reproductive Toxicity.-Avian Models in Teratology and Developmental Toxicology.-Overview of In Vitro Models in Developmental Toxicology.-Primary Cell and Micromass Culture in Assessing Developmental Toxicity.-Embryonic Stem Cell Test (EST): Stem cell Use in Predicting Developmental Cardiotoxicity and Osteotoxicity.-Mouse Embryonic Stem Cell Adherent Cell Differentiation and Cytotoxicity (ACDC) Assay.-The Murine Limb Bud in Culture as an In Vitro Teratogenicity Test System.-Rodent Whole Embryo Culture.-Rabbit Whole Embryo Culture.-Assessment of Xenobiotic Biotransformation Including Reactive Oxygen Species Generation in the Embryo using Benzene as an Example.-Methodological Approaches to Cytochrome P450 Profiling in Embryos.-Analysis of Nrf2-Mediated Transcriptional Induction of Antioxidant Response in Early Embryos.-Regulation and Control of AP-1 Binding Activity in Embryotoxicity.-Thioredoxin Redox Status Assessment During Embryonic Development: The Redox Western.-Methods for the Determination of Plasma or Tissue Glutathione Levels.-Oxidative Stress, Thiols, and Redox Profiles.-A Review of Toxicogenomic Approaches in Developmental Toxicology.-Epigenetic Approaches and Methods in Developmental Toxicology: Role of HDAC Inhibition in Teratogenic Events.-DNA Methylation Screening and Analysis.-Assessment of Histiotrophic Nutrition using Fluorescent Probes.-Diabetic Embryopathy.-Gene Expression Analysis in Developing Embryos: In situ Hybridization.-Assessment of Gross Fetal Malformations: The Modernized Wilson Technique and Skeletal Staining.