This book constitutes the refereed proceedings of the 10th International Conference on Detection of Intrusions and Malware, and Vulnerability Assessment, DIMVA 2013, held in Berlin, Germany, in July 2013. The 9 revised full papers presented together with 3 short papers were carefully reviewed and selected from 38 submissions. The papers are organized in topical sections on malware; network security, Web security; attacks and defenses; and host security.