Madhukar Trivedi is Professor of Psychiatry, Chief of the Division of Mood Disorders, and Founding Director of the Center for Depression Research and Clinical Care at UT Southwestern Medical Center. He is an internationally recognized translational researcher focusing on developing and validating biosignatures of depression. He specializes in treating depression and conducts research on pharmacological, psychosocial, and nonpharmacological treatments for depression, including ketamine, magnetic stimulation, and exercise.Holding the Betty Ho Hay Distinguished Chair in Mental Health and the Julie K. Hersh Chair for Depression Research and Clinical Care at UTSW, Dr. Trivedi has received numerous accolades, including the Psychiatric Excellence Award from the Texas Society of Psychiatric Physicians and the Gerald Klerman Senior Investigator Award from the Depression and Bipolar Support Alliance. With over 500 articles and chapters related to the diagnosis and treatment of mood disorders, Dr.Trivedi was listed on Thomas Reuters' World's Most Influential Scientific Minds in each year since 2014 as one of the most highly cited researchers in the U.S. field of Psychiatry.Series editor: Steven M. Strakowski, MD, Founding Chair, Department of Psychiatry, Dell Medical School, University of Texas, Austin

• 1.Introduction and OverviewI. Etiology/Pathophysiology 2. Neurobiology 3. Genetic Risk Factors 4. Environmental and Social Risk Factors 5. Blood-based Biomarkers II. Comorbidities and Differential Diagnoses 6. Anxiety Disorders 7. Bipolar Disorder 8. Suicidality 9. General Medical Conditions 10. General Medical Conditions, Metabolic DisordersIII. Pharmacotherapy for Depression 11. First line and combination therapeutics 12. Augmentation strategies 13. Rapid-acting antidepressants 14. Side Effects of Antidepressant15. Strategies for targeting residual symptoms IV. Psychotherapy and modalities of delivery for Depression16. Cognitive Behavioral Therapy/Behavioral Activation 17. Behavioral Activation for Depression 18. Psychodynamic and Supportive Psychotherapy 19. ECT/TMSV. Novel, Non-Traditional Treatment Strategies for Depression20. Exercise as a treatment for depression21. Therapeutic Mindfulness For Relapse Prophylaxis in Unipolar Depression22. Probiotics and Neutraceuticals23. Chronobiological Treatments: Sleep and Light TherapiesVI. Special Populations in Depression24. Children and Adolescents25. Elderly Patients26. Pregnant and Postpartum27. Depression Following Mild Traumatic Brain Injury 28. Treatment in Primary CareVII. MISCELLANEOUS 29. Future Directions: Precision Medicine and Biosignatures

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Madhukar Trivedi is Professor of Psychiatry, Chief of the Division of Mood Disorders, and Founding Director of the Center for Depression Research and Clinical Care at UT Southwestern Medical Center. He is an internationally recognized translational researcher focusing on developing and validating biosignatures of depression. He specializes in treating depression and conducts research on pharmacological, psychosocial, and nonpharmacological treatments for depression, including ketamine, magnetic stimulation, and exercise.Holding the Betty Ho Hay Distinguished Chair in Mental Health and the Julie K. Hersh Chair for Depression Research and Clinical Care at UTSW, Dr. Trivedi has received numerous accolades, including the Psychiatric Excellence Award from the Texas Society of Psychiatric Physicians and the Gerald Klerman Senior Investigator Award from the Depression and Bipolar Support Alliance. With over 500 articles and chapters related to the diagnosis and treatment of mood disorders, Dr.Trivedi was listed on Thomas Reuters' World's Most Influential Scientific Minds in each year since 2014 as one of the most highly cited researchers in the U.S. field of Psychiatry.Series editor: Steven M. Strakowski, MD, Founding Chair, Department of Psychiatry, Dell Medical School, University of Texas, Austin

• 1.Introduction and OverviewI. Etiology/Pathophysiology 2. Neurobiology 3. Genetic Risk Factors 4. Environmental and Social Risk Factors 5. Blood-based Biomarkers II. Comorbidities and Differential Diagnoses 6. Anxiety Disorders 7. Bipolar Disorder 8. Suicidality 9. General Medical Conditions 10. General Medical Conditions, Metabolic DisordersIII. Pharmacotherapy for Depression 11. First line and combination therapeutics 12. Augmentation strategies 13. Rapid-acting antidepressants 14. Side Effects of Antidepressant15. Strategies for targeting residual symptoms IV. Psychotherapy and modalities of delivery for Depression16. Cognitive Behavioral Therapy/Behavioral Activation 17. Behavioral Activation for Depression 18. Psychodynamic and Supportive Psychotherapy 19. ECT/TMSV. Novel, Non-Traditional Treatment Strategies for Depression20. Exercise as a treatment for depression21. Therapeutic Mindfulness For Relapse Prophylaxis in Unipolar Depression22. Probiotics and Neutraceuticals23. Chronobiological Treatments: Sleep and Light TherapiesVI. Special Populations in Depression24. Children and Adolescents25. Elderly Patients26. Pregnant and Postpartum27. Depression Following Mild Traumatic Brain Injury 28. Treatment in Primary CareVII. MISCELLANEOUS 29. Future Directions: Precision Medicine and Biosignatures

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Madhukar Trivedi is Professor of Psychiatry, Chief of the Division of Mood Disorders, and Founding Director of the Center for Depression Research and Clinical Care at UT Southwestern Medical Center. He is an internationally recognized translational researcher focusing on developing and validating biosignatures of depression. He specializes in treating depression and conducts research on pharmacological, psychosocial, and nonpharmacological treatments for depression, including ketamine, magnetic stimulation, and exercise.Holding the Betty Ho Hay Distinguished Chair in Mental Health and the Julie K. Hersh Chair for Depression Research and Clinical Care at UTSW, Dr. Trivedi has received numerous accolades, including the Psychiatric Excellence Award from the Texas Society of Psychiatric Physicians and the Gerald Klerman Senior Investigator Award from the Depression and Bipolar Support Alliance. With over 500 articles and chapters related to the diagnosis and treatment of mood disorders, Dr.Trivedi was listed on Thomas Reuters' World's Most Influential Scientific Minds in each year since 2014 as one of the most highly cited researchers in the U.S. field of Psychiatry.Series editor: Steven M. Strakowski, MD, Founding Chair, Department of Psychiatry, Dell Medical School, University of Texas, Austin

• 1.Introduction and OverviewI. Etiology/Pathophysiology 2. Neurobiology 3. Genetic Risk Factors 4. Environmental and Social Risk Factors 5. Blood-based Biomarkers II. Comorbidities and Differential Diagnoses 6. Anxiety Disorders 7. Bipolar Disorder 8. Suicidality 9. General Medical Conditions 10. General Medical Conditions, Metabolic DisordersIII. Pharmacotherapy for Depression 11. First line and combination therapeutics 12. Augmentation strategies 13. Rapid-acting antidepressants 14. Side Effects of Antidepressant15. Strategies for targeting residual symptoms IV. Psychotherapy and modalities of delivery for Depression16. Cognitive Behavioral Therapy/Behavioral Activation 17. Behavioral Activation for Depression 18. Psychodynamic and Supportive Psychotherapy 19. ECT/TMSV. Novel, Non-Traditional Treatment Strategies for Depression20. Exercise as a treatment for depression21. Therapeutic Mindfulness For Relapse Prophylaxis in Unipolar Depression22. Probiotics and Neutraceuticals23. Chronobiological Treatments: Sleep and Light TherapiesVI. Special Populations in Depression24. Children and Adolescents25. Elderly Patients26. Pregnant and Postpartum27. Depression Following Mild Traumatic Brain Injury 28. Treatment in Primary CareVII. MISCELLANEOUS 29. Future Directions: Precision Medicine and Biosignatures

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