V. Olga B. Emery, Ph.D., is an adjunct associate professor of psychiatry at Dartmouth Medical School and director of the New Hampshire Center on Aging, Health and Society. She also holds an appointment at Harvard Medical School. Thomas E. Oxman, M.D., is a professor of psychiatry and community and family medicine at Dartmouth Medical School.

• Contents:List of Contributors Acknowledgments List of Abbreviations IntroductionPART ONE: Background, Concepts, and Diagnostics1. Boundaries between Normal Aging and Dementia: Perspectives from Neuropsychological and Neuroimaging Investigations 2. The Spectrum of Dementias: Construct and Nosologic Validity 3. Diagnostic Procedures for Dementia PART TWO: Alzheimer Dementias4. The Neuropathology of Alzheimer Dementia 5. Neural Inflammatory Mechanisms in Alzheimer Syndrome 6. Clinical Subgroups of Alzheimer Disease 7. Progressive Aphasia, Frontotemporal Dementia and Other "Focal Dementias" 8. "Retrophylogenesis" of Memory in Dementia of the Alzheimer Type: A New Evolutionary Memory FrameworkPART THREE: Vascular Dementias and Subcortical Dementias9. Cortical and Frontosubcortical Dementias: Differential Diagnosis 10. Noninfarct Vascular Dementia: The Spectrum of Vascular Dementia and Alzheimer Syndrome 11. The Relationship of Hypertension to Vascular Dementia 12. Vascular Dementias and Alzheimer Disease: Differential Diagnosis 13. Acquired Immunodeficiency Syndrome Dementia ComplexPART FOUR: Depressive Dementias14. Depressive Dementia: A "Prepermanent Intermediate-stage Dementia" in a Long-term Disease Course of Permanent Dementia? 15. Depressive Dementia: Cognitive and Biological Correlated and Course of Illness 16. The Nondepressive Pseudodementias 17. Neurobiology of Major Depression in Alzheimer Disease 18. Approaches to the Treatment of Dementing Illness 19. The Spectra of the Dementias Index

A forward-thinking contribution to the field of dementia and is commendable for its goal of striving beyond overly simplistic, formulaic conventions. It would be well placed on the library shelf of the curious and contemplative cognitive clinician. -- Daniel Kaufer, M.D. New England Journal of Medicine A major contribution to dementia research... An excellent reference text for those exploring both the uncharted areas of research and some of the clinical aspects of dementia. -- Matthew Robillard, MD Canadian Journal of Psychiatry A valuable addition to our understanding of the conditions that erode our memory. -- Frances R. Frankenburg, M.D. American Journal of Psychiatry 2005 Timely publication... Stimulating and thorough coverage. -- Mark Walterfang International Psychogeriatrics 2004

V. Olga B. Emery, Ph.D., is an adjunct associate professor of psychiatry at Dartmouth Medical School and director of the New Hampshire Center on Aging, Health and Society. She also holds an appointment at Harvard Medical School. Thomas E. Oxman, M.D., is a professor of psychiatry and community and family medicine at Dartmouth Medical School.

• Contents:List of Contributors Acknowledgments List of Abbreviations IntroductionPART ONE: Background, Concepts, and Diagnostics1. Boundaries between Normal Aging and Dementia: Perspectives from Neuropsychological and Neuroimaging Investigations 2. The Spectrum of Dementias: Construct and Nosologic Validity 3. Diagnostic Procedures for Dementia PART TWO: Alzheimer Dementias4. The Neuropathology of Alzheimer Dementia 5. Neural Inflammatory Mechanisms in Alzheimer Syndrome 6. Clinical Subgroups of Alzheimer Disease 7. Progressive Aphasia, Frontotemporal Dementia and Other "Focal Dementias" 8. "Retrophylogenesis" of Memory in Dementia of the Alzheimer Type: A New Evolutionary Memory FrameworkPART THREE: Vascular Dementias and Subcortical Dementias9. Cortical and Frontosubcortical Dementias: Differential Diagnosis 10. Noninfarct Vascular Dementia: The Spectrum of Vascular Dementia and Alzheimer Syndrome 11. The Relationship of Hypertension to Vascular Dementia 12. Vascular Dementias and Alzheimer Disease: Differential Diagnosis 13. Acquired Immunodeficiency Syndrome Dementia ComplexPART FOUR: Depressive Dementias14. Depressive Dementia: A "Prepermanent Intermediate-stage Dementia" in a Long-term Disease Course of Permanent Dementia? 15. Depressive Dementia: Cognitive and Biological Correlated and Course of Illness 16. The Nondepressive Pseudodementias 17. Neurobiology of Major Depression in Alzheimer Disease 18. Approaches to the Treatment of Dementing Illness 19. The Spectra of the Dementias Index

A forward-thinking contribution to the field of dementia and is commendable for its goal of striving beyond overly simplistic, formulaic conventions. It would be well placed on the library shelf of the curious and contemplative cognitive clinician. -- Daniel Kaufer, M.D. New England Journal of Medicine A major contribution to dementia research... An excellent reference text for those exploring both the uncharted areas of research and some of the clinical aspects of dementia. -- Matthew Robillard, MD Canadian Journal of Psychiatry A valuable addition to our understanding of the conditions that erode our memory. -- Frances R. Frankenburg, M.D. American Journal of Psychiatry 2005 Timely publication... Stimulating and thorough coverage. -- Mark Walterfang International Psychogeriatrics 2004

V. Olga B. Emery, Ph.D., is an adjunct associate professor of psychiatry at Dartmouth Medical School and director of the New Hampshire Center on Aging, Health and Society. She also holds an appointment at Harvard Medical School. Thomas E. Oxman, M.D., is a professor of psychiatry and community and family medicine at Dartmouth Medical School.

• Contents:List of Contributors Acknowledgments List of Abbreviations IntroductionPART ONE: Background, Concepts, and Diagnostics1. Boundaries between Normal Aging and Dementia: Perspectives from Neuropsychological and Neuroimaging Investigations 2. The Spectrum of Dementias: Construct and Nosologic Validity 3. Diagnostic Procedures for Dementia PART TWO: Alzheimer Dementias4. The Neuropathology of Alzheimer Dementia 5. Neural Inflammatory Mechanisms in Alzheimer Syndrome 6. Clinical Subgroups of Alzheimer Disease 7. Progressive Aphasia, Frontotemporal Dementia and Other "Focal Dementias" 8. "Retrophylogenesis" of Memory in Dementia of the Alzheimer Type: A New Evolutionary Memory FrameworkPART THREE: Vascular Dementias and Subcortical Dementias9. Cortical and Frontosubcortical Dementias: Differential Diagnosis 10. Noninfarct Vascular Dementia: The Spectrum of Vascular Dementia and Alzheimer Syndrome 11. The Relationship of Hypertension to Vascular Dementia 12. Vascular Dementias and Alzheimer Disease: Differential Diagnosis 13. Acquired Immunodeficiency Syndrome Dementia ComplexPART FOUR: Depressive Dementias14. Depressive Dementia: A "Prepermanent Intermediate-stage Dementia" in a Long-term Disease Course of Permanent Dementia? 15. Depressive Dementia: Cognitive and Biological Correlated and Course of Illness 16. The Nondepressive Pseudodementias 17. Neurobiology of Major Depression in Alzheimer Disease 18. Approaches to the Treatment of Dementing Illness 19. The Spectra of the Dementias Index

A forward-thinking contribution to the field of dementia and is commendable for its goal of striving beyond overly simplistic, formulaic conventions. It would be well placed on the library shelf of the curious and contemplative cognitive clinician. -- Daniel Kaufer, M.D. New England Journal of Medicine A major contribution to dementia research... An excellent reference text for those exploring both the uncharted areas of research and some of the clinical aspects of dementia. -- Matthew Robillard, MD Canadian Journal of Psychiatry A valuable addition to our understanding of the conditions that erode our memory. -- Frances R. Frankenburg, M.D. American Journal of Psychiatry 2005 Timely publication... Stimulating and thorough coverage. -- Mark Walterfang International Psychogeriatrics 2004