This book constitutes the proceedings of the 5th Workshop on Deep Generative Models for Medical Image Computing and Computer Assisted Intervention, DGM4MICCAI 2025, held in conjunction with the 28th International Conference on Medical Image Computing and Computer Assisted Intervention, MICCAI 2025, in Daejeon, South Korea, during September 2025.The 33 papers presented in this book were carefully reviewed and selected from 50 submissions. These papers deal with recent algorithmic developments, new results, and promising future directions in Deep Generative Models.