Deep Brain Stimulation

Kendall H. Lee is a consultant in the Department of Neurologic Surgery with joint appointments in the Department of Physiology and Biomedical Engineering and the Department of Physical Medicine and Rehabilitation at Mayo Clinic and founder of NaviNetics, Inc, a medical device company. He joined the staff of Mayo Clinic in 2006. He is the Charles B. and Ann L. Johnson Professor of Neurosurgery and holds the academic rank of professor of biomedical engineering. He also founded Neural Engineering and Precision Surgery Laboratories and is currently a director emeritus at Mayo Clinic. Dr Lee is an expert on neurological disorders and sees patients with Parkinson’s disease, essential tremor, Tourette syndrome, dystonia and other neurodegenerative diseases. His research focuses on developing deep brain stimulation for the treatment of Parkinson's disease, tremor, depression, obsessive-compulsive disorder, and epilepsy. Beyond these movement disorders, his recent research has expanded into the field of psychiatric disorders, and he is actively developing new surgical frames to enhance both surgical precision and patient comfort.Jin Woo Chang is a professor at Korea University Anam Hospital and the first president of Asian Pacific Society for Transcranial Focused Ultrasound Surgery. He specializes in stereotactic and functional neurosurgery, and his main interest is the neuromodulation of the central nervous system with new innovative techniques, such as electrical stimulation and focused ultrasound. Dr Chang has published more than 270 academic papers in SCI(E) journals around the world. He is a co-author of more than eight prominent neurosurgery textbooks and has authored countless domestic papers and textbooks. Currently Dr Chang serves as a section editor of the journal World Neurosurgery and an editorial board member of the journals Stereotactic and Functional Neurosurgery and Neuromodulation.

• SECTION 1: INTRODUCTION AND HUMANITIES 1. Overview of the History and Application of Deep Brain Stimulation 2. Ethical Considerations in the Use of Deep Brain Stimulation SECTION 2: NEURAL ENGINEERING 3. The Mathematics of Stereotactic Neurosurgery 4. Biophysical Fundamentals of Neural Excitation 5. Electrochemical Measurements of Neurochemical Concentrations: Dopamine 6. Electrochemical Measurements of Neurochemical Concentrations: Serotonin 7. Closed-Loop Control Systems for Deep Brain Stimulation Therapy SECTION 3: CLINICAL APPLICATIONS IN NEUROLOGY 8. Deep Brain Stimulation for Parkinson’s Disease 9. Deep Brain Stimulation for Tremor 10. MRI-Guided Focused Ultrasound Therapy for Tremor 11. Deep Brain Stimulation for Dystonia 12. Current Outcomes of Deep Brain Stimulation for Treatment of Motor Disability in Patients with Cerebral Palsy 13. Deep Brain Stimulation for Chronic Pain 14. Motor Cortex Stimulation and its Applications for Intractable Chronic Pain 15. Deep Brain Stimulation for Medically Refractory Epilepsy 16. Deep Brain Stimulation for Trigeminal Autonomic Cephalalgias 17. Deep Brain Stimulation for Memory Dysfunction 18. Aesthetic Considerations in Deep Brain Stimulation Surgery SECTION 4: CLINICAL APPLICATIONS IN PSYCHIATRY 19. Deep Brain Stimulation for Obsessive-Compulsive Disorder 20. Deep Brain Stimulation for Tourette’s Syndrome 21. Deep Brain Stimulation for Treatment-Resistant Depression 22. Anorexia Nervosa and Deep Brain Stimulation: Current Evidence and Future Directions 23. Deep Brain Stimulation for Substance Use Disorder 24. Deep Brain Stimulation: a Potential Long-Term Therapeutic Modality in Treating Schizophrenia 25. Deep Brain Stimulation for Disorders of Consciousness 26. Deep Brain Stimulation and its Applications for Post-Traumatic Stress Disorder SECTION 5: NEUROSCIENCE OF NEUROMODULATION 27. Motor Circuit Activity in Parkinson’s Disease 28. The Role of Astrocytes in Deep Brain Stimulation 29. Anatomy of the Globus Pallidus Internus 30. STN Anatomic Subregions and Targeting Implications 31. Voltammetric Measurements of Neurochemical Signals in Humans Associated with Behavior, Cognition, and Related Pathologies

“This book covers diverse topics of relevance for current practitioners as well as newcomers to the field, including theoretical and mechanistic aspects, results of important clinical trials, and potential new brain targets and new indications.”Dr Philip A. StarrUniversity of California, San Francisco, USA