Deciphering The Role of Succinate Dehydrogenase in Drug Discovery

SDH in Drug Discovery

Inbunden, Engelska, 2025

Av Vaishali Manikrao Patil, Dileep Kumar, Satya P. Gupta

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The book explores various aspects of Succinate Dehydrogenase (SDH) (an enzyme crucial for cellular respiration and energy production) from its assembly and regulation mechanisms to its deficiency and its implications in related disorders. It also encompasses the impact of SDH in obstructive pulmonary disorders, discussing its potential contributions and implications. It explores the design and development of SDH inhibitors as potent agent against fungal infections. It further examines the relationship between SDH mutations and cancer development, linking genetic alterations to tumorigenesis.The book focuses on therapeutic strategies and highlights the role of SDH in managing gastrointestinal tumors, neurodegenerative disorders, and aging-related diseases. It navigates through the challenges and prospects of utilizing SDH as a target for therapeutic interventions. The book also dives into the diagnostic aspects of SDH defects, elucidating their implications and potential diagnostic investigations. It serves as a comprehensive guide to unravel SDH's functions, dysfunctions, and therapeutic potentials.By amalgamating diverse areas such as enzymology, genetics, pharmacology, and disease management, this book emerges as an invaluable resource for researchers, clinicians, and students alike.

Produktinformation

Utgivningsdatum2025-06-12
Mått155 x 235 x 23 mm
Vikt633 g
FormatInbunden
SpråkEngelska
Antal sidor298
FörlagSpringer Nature Switzerland AG
ISBN9789819668304

Tillhör följande kategorier

Medicinsk utrustning och medicinska tekniker inom Medicin
Farmakologi inom Medicin
Biokemisk teknik inom Naturvetenskap och teknik

Dr. Vaishali M. Patil completed her bachelor’s in pharmacy from North Maharashtra University (MS), masters in pharmaceutical chemistry from Dr. A. P. J. Abdul Kalam Technical University (UP) and doctorate from Birla Institute of Technology, Ranchi, India. Dr. Patil is Associate Professor and Principal at Charak School of Pharmacy, Chaudhary Charan Singh University, Meerut, India. She has served as Visiting Professor, Faculty of Pharmaceutical Sciences, UCSI University, Kuala Lumpur, Malaysia. Dr. Patil has more than 17 years of experience in academics and research. Her research interest is in rational drug design with specialization in quantitative structure-activity relationship studies of biologically active molecules, drug-receptor interactions, and synthesis of small heterocyclic molecules. Dr. Patil has published more than 90 research articles in the peer-reviewed journals and authored numerous books and book chapters.Dr. Dileep Kumar received his B. Pharm from Manipal College of Pharmaceutical Sciences, Manipal University, India, and M. Pharm from S.G.S.I.T.S Indore, Madhya Pradesh, India. He was awarded junior research fellowship by National Medicinal Plant Board (NMPB) New Delhi, senior research fellowship from University Grants Commission (UGC), teaching assistantship and institute post-doctoral fellowship from IIT (BHU) Varanasi, India. He worked as an assistant professor in Poona College of Pharmacy, Bharti Vidyapeeth University, Pune, India. He published more than 100 papers in his academic career.Dr. Satya P. Gupta has served at Tata Institute of Fundamental Research (TIFR), Mumbai and as Professor at Birla Institute of Technology and Science, Pilani and then MIET as its Director-cum Professor of Eminence. Prof. Gupta has worked as Professor in the department of applied sciences at National Institute of Technical Teachers’ Training and Research, Bhopal, India. Prof. Gupta has a very long standing of teaching quantum chemistry, pharmaceutical chemistry, biophysics, and drug design. He had obtained his M. Sc and D. Phil degrees from University of Allahabad, Allahabad, India in 1967 and 1971, respectively. For his work in drug design, he has bagged several honors and awards.

Chapter 1. Succinate Dehydrogenase: Structure, Function and Significance.- Chapter 2. The Function of Succinate Dehydrogenase in Maintaining Normal Health.- Chapter 3. Role of Succinate Dehydrogenase in Cellular Respiration.- Chapter 4. Succinate Dehydrogenase: An Important Target in Drug Discovery for Tropical and Neglected Diseases.- Chapter 5. Succinate Dehydrogenase in Mitochondrial Disorders.- Chapter 6. Role of SDH in Cardiovascular Disorders.- Chapter 7. Implication of Succinate Dehydrogenase in Cancer.- Chapter 8. SDH and its Impact on Neurodegenerative Diseases: Autophagy in Neuroinflammation Perspective.- Chapter 9. Neurodegenerative Diseases and Succinate Dehydrogenase: A Therapeutics Avenue for Treatment.- Chapter 10. Fungicidal SDH Inhibitors in Agriculture: Regulation and Future Perspectives.- Chapter 11. Metabolic Disorders and Succinate Dehydrogenase.