This book constitutes the post-conference proceedings of the 25th International Conference on Data Analytics and Management in Data Intensive Domains, DAMDID/RCDL 2023, held in Moscow, Russia, during 24-27 October 2023.The 21 papers presented here were carefully reviewed and selected from 75 submissions. These papers are organized in the following topical sections: Data Models and Knowledge Graphs; Databases in Data Intensive Domains; Machine learning methods and applications; Data Analysis in Astronomy & Information extraction from text. Papers from keynote talks have also been included in this book.