Del 174 - Progress in Molecular Biology and Translational Science

Dancing Protein Clouds: Intrinsically Disordered Proteins in Health and Disease, Part B

Inbunden, Engelska, 2020

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Dancing Protein Clouds: Intrinsically Disordered Proteins in Health and Disease, Part B, represents a set of selected studies on a variety of research topics related to intrinsically disordered proteins. Topics in this update include structural and functional characterization of several important intrinsically disordered proteins, such as 14-3-3 proteins and their partners, as well as proteins from muscle sarcomere; representation of intrinsic disorder-related concept of protein structure-function continuum; discussion of the role of intrinsic disorder in phenotypic switching; consideration of the role of intrinsically disordered proteins in the pathogenesis of neurodegenerative diseases and cancer; discussion of the roles of intrinsic disorder in functional amyloids; demonstration of the usefulness of the analysis of translational diffusion of unfolded and intrinsically disordered proteins; consideration of various computational tools for evaluation of functions of intrinsically disordered regions; and discussion of the role of shear stress in the amyloid formation of intrinsically disordered regions in the brain.

Provides some recent studies on the intrinsically disordered proteins and their functions, as well as on the involvement of intrinsically disordered proteins in pthogenesis of various diseases
Contains numerous illustrative materials (color figures, diagrams, and tables) to help the readers to delve in the information provided
Includes contributions from recognized experts in the field

Produktinformation

Utgivningsdatum2020-08-19
Mått152 x 229 x undefined mm
Vikt770 g
FormatInbunden
SpråkEngelska
SerieProgress in Molecular Biology and Translational Science
Antal sidor402
FörlagElsevier Science
MedarbetareUversky,VladimirN
ISBN9780128226155

Tillhör följande kategorier

Biologi inom Naturvetenskap och teknik
Biokemi inom Naturvetenskap och teknik

Prof. Vladimir N. Uversky, PhD, DSc, FRSB, FRSC, F.A.I.M.B.E., Professor at the Department of Molecular Medicine, Morsani College of Medicine, University of South Florida (USF), is a pioneer in the field of protein intrinsic disorder. He has made a number of groundbreaking contributions in the field of protein folding, misfolding, and intrinsic disorder. He obtained his PhD from Moscow Institute of Physics and Technology and D.Sc. from the Institute of Experimental and Theoretical Biophysics, Russian Academy of Sciences. Since 2010, Professor Uversky has worked at University of South Florida, where he works on various aspects of protein intrinsic disorder phenomenon and analysis of protein folding and misfolding processes. He has authored over 1250 scientific publications and edited several books and book series on protein structure, function, folding, misfolding, and intrinsic disorder. He also servs as an editor in a number of scientific journals.

PrefaceVladimir N. Uversky1. Intrinsically disordered proteins of viruses: Involvement in the mechanism of cell regulation and pathogenesisPushpendra Mani Mishra, Navneet C Verma, Chethana Rao, Vladimir N Uversky and Chayan K Nandi2. Transient knots in intrinsically disordered proteins and neurodegenerationMarek Cieplak, Mateusz Chwastyk, Łukasz Mioduszewski and Belisa R. H. de Aquino3. IDPs and their complexes in GPCR and nuclear receptor signalingMyriam Guillien, Albane le Maire, Assia Mouhand, Pau Bernadó, William Bourguet, Jean-Louis Banères and Nathalie Sibille4. Intrinsic disorder-based design of stable globular proteinsGalina S. Nagibina, Tatiana N. Melnik, Ksenia A. Glukhova, Vladimir N. Uversky and Bogdan S. Melnik5. The pathophysiology of neurodegenerative disease: Disturbing the balance between phase separation and irreversible aggregationChelsea J. Webber, Shuwen (Eric) Lei and Benjamin Wolozin6. Context-dependent HOX transcription factor function in health and disease Sarah E. Bondos, Gabriela Geraldo Mendes and Amanda Jons7. Dancing while self-eating: Protein intrinsic disorder in autophagyHana Popelka8. Intrinsic disorder in the nickel-dependent urease networkBarbara Zambelli, Luca Mazzei and Stefano Ciurli9. Disorder and cysteines in proteins: A design for orchestration of conformational see-saw and modulatory functionsAnukool A. Bhopatkar, Vladimir N. Uversky and Vijayaraghavan Rangachari