Del 166 - Progress in Molecular Biology and Translational Science

Dancing protein clouds: Intrinsically disordered proteins in health and disease, Part A

Inbunden, Engelska, 2019

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"Dancing protein clouds: Intrinsically disordered proteins in the norm and pathology" represents a set of selected studies on a variety of research topics related to intrinsically disordered proteins. Topics in this update include structural and functional characterization of several important intrinsically disordered proteins, such as 14-3-3 proteins and their partners, as well as proteins from muscle sarcomere; representation of intrinsic disorder-related concept of protein structure-function continuum; discussion of the role of intrinsic disorder in phenotypic switching; consideration of the role of intrinsically disordered proteins in the pathogenesis of neurodegenerative diseases and cancer; discussion of the roles of intrinsic disorder in functional amyloids; demonstration of the usefulness of the analysis of translational diffusion of unfolded and intrinsically disordered proteins; consideration of various computational tools for evaluation of functions of intrinsically disordered regions; and discussion of the role of shear stress in the amyloid formation of intrinsically disordered regions in the brain.

Provides some recent studies on the intrinsically disordered proteins and their functions, as well as on the involvement of intrinsically disordered proteins in pthogenesis of various diseases
Contains numerous illustrative materials (color figures, diagrams, and tables) to help the readers to delve in the information provided
Includes contributions from recognized experts in the field

Produktinformation

Utgivningsdatum2019-09-12
Mått152 x 229 x undefined mm
Vikt820 g
FormatInbunden
SpråkEngelska
SerieProgress in Molecular Biology and Translational Science
Antal sidor424
FörlagElsevier Science
MedarbetareUversky,VladimirN
ISBN9780128168516

Tillhör följande kategorier

Biologi inom Naturvetenskap och teknik
Biokemi inom Naturvetenskap och teknik

Prof. Vladimir N. Uversky, PhD, DSc, FRSB, FRSC, F.A.I.M.B.E., Professor at the Department of Molecular Medicine, Morsani College of Medicine, University of South Florida (USF), is a pioneer in the field of protein intrinsic disorder. He has made a number of groundbreaking contributions in the field of protein folding, misfolding, and intrinsic disorder. He obtained his PhD from Moscow Institute of Physics and Technology and D.Sc. from the Institute of Experimental and Theoretical Biophysics, Russian Academy of Sciences. Since 2010, Professor Uversky has worked at University of South Florida, where he works on various aspects of protein intrinsic disorder phenomenon and analysis of protein folding and misfolding processes. He has authored over 1250 scientific publications and edited several books and book series on protein structure, function, folding, misfolding, and intrinsic disorder. He also servs as an editor in a number of scientific journals.

1. Protein intrinsic disorder and structure-function continuumVladimir N. Uversky2. Intrinsic disorder associated with 14-3-3 proteins and their partnersNikolai N. Sluchanko and Diego M. Bustos3. Intrinsically disordered proteins and phenotypic switching: Implications in cancerVivek Kulkarni and Prakash Kulkarni4. Translational diffusion of unfolded and intrinsically disordered proteinsIrina V. Nesmelova, Daria L. Melnikova, Venkatesh Ranjan and Vladimir D. Skirda5. Intrinsically disordered proteins in the formation of functional amyloids from bacteria to humansAnamika Avni, Hema M. Swasthi, Anupa Majumdar and Samrat Mukhopadhyay6. Intrinsically disordered proteins in various hypotheses on the pathogenesis of Alzheimer's and Parkinson's diseasesOrkid Coskuner and Vladimir N. Uversky7. Shear-induced amyloid formation of IDPS in the brainConrad N. Trumbore8. Role of intrinsic disorder in muscle sarcomeresDmitri Tolkatchev, Garry E. Smith Jr. and Alla S. Kostyukova9. Computational prediction of functions of intrinsically disordered regionsAkila Katuwawala, Sina Ghadermarzi and Lukasz Kurgan10. The dark proteome of cancer: Intrinsic disorderedness and functionality of HIF-1α along with its interacting proteinsNeha Garg, Prateek Kumar, Kundlik Gadhave and Rajanish Giri