Current Approaches to Overcome Therapeutic Resistance of Leukemia

Zhe-Sheng Chen, PhD, opened the St. John’s University’s first cancer pharmacology laboratory. His research interest is multidrug resistance and its reversal, novel anti-cancer drug development. Chen has over 170 papers published, co-edited Protein Kinase Inhibitors as Sensitizing Agents for Chemotherapy book (Elsevier), and holds several patents. Dr. Saurabh Kumar Jha is an Assistant Professor in the Department of Stem Cell Biology at Kalindi College, University of Delhi. He holds an M.Sc. in Biotechnology from VIT University, Vellore, and a Ph.D. in Biotechnology (Neurobiology) from Delhi Technological University. His research focuses on stem cell biology, with particular expertise in molecular chaperones, ubiquitin E3 ligases, and biomolecular therapeutics in neurodegenerative disorders and aging. Dr. Jha has an extensive publication record, with hundreds of research articles in high-impact international journals and multiple book chapters with leading academic publishers. He is the recipient of the Best Stem Cell Researcher Award (2019). He has actively contributed to curriculum development and has supervised doctoral and master’s students, alongside participating in international conferences and professional societies. Dr. Neha Gupta is an Assistant Professor in Biotechnology at Jiwaji University, Gwalior, with a Ph.D. in Biotechnology and extensive experience in research and teaching. She has received multiple awards recognizing her research excellence in biological sciences and has held an international research role in microbiology and molecular biology. Her academic background includes teaching, mentoring postgraduate students, and guiding research projects. Her scholarly contributions include numerous publications, as well as authorship of a patent, a book, and several book chapters. She has actively participated in national and international conferences. Her research focuses on bioactive compounds derived from food, their biological functions, and the application of advanced screening, bioinformatics, and computational approaches.

• Part I: Mechanisms of Resistance1. The Biology of Resistance in Leukemia: From Cells to Niches2. Leukemia Drug Resistance: Molecular Insights and PathwaysPart II: Emerging Resistance Mechanisms3. Leukemia Resistance Unveiled: Stem Cells, Microenvironment, and Evolving Mechanisms4. Non-Genetic and Epigenetic Rewiring in Leukemia Resistance5. Epigenetic and Metabolic Drivers of Immune Tolerance and Evasion in LeukemiaPart III: Breaking the Barrier6. Breaking Resistance in Leukemia: CAR-T, PROTACs, and Beyond7. Defeating Leukemia Resistance: Emerging Therapeutic FrontiersPart IV: Clinical Translation and Future Directions8. Clinical Translation of Leukemia Therapies: AI-Driven Drug Discovery and Liquid Biopsy9. From Bench to Bedside in Leukemia: AI and Liquid Biopsy in Resistance Management10. AI-Enabled Immunotherapy in Leukemia: Emerging Approaches to Combat Resistance