Cuproptosis in Oncology

Cuproptosis in Oncology: Pathogenic Mechanisms and Emerging Therapeutic Opportunities offers a comprehensive study of this novel form of regulated cell death driven by copper-induced mitochondrial stress, and its significance in cancer. The book begins with foundational chapters on the fundamentals of cuproptosis, its molecular mechanisms, and significance of copper homeostasis in cellular physiology, setting the stage for advanced discussions on its role in oncogenesis. Subsequent sections investigate cuproptosis in cancer progression, including how dysregulated cuproptosis influences tumor initiation, proliferation, metastasis, and therapy resistance. This is followed by an evaluation of innovative therapeutic approaches, including copper chelators, nanomedicine, small-molecule modulators, and combination therapies, highlighting their potential to revolutionize cancer treatment. The final section considers translational and clinical perspectives, including cuproptosis biomarkers for diagnosis and prognosis in oncology, clinical trials targeting cuproptosis, and future perspectives regarding the integration of omics, systems biology and precision medicine for therapeutic innovation. This volume unearths the critical role of copper homeostasis in tumor development and progression, laying the foundation for future translational advances. It serves as an invaluable resource for biomedical researchers including cell biologists, pharmacologists and oncologists, seeking to understand and target copper-dependent cell death pathways.

• Explains the molecular mechanisms underlying cuproptosis and its relevance in cancer biology
• Highlights therapeutic strategies for early cancer detection and treatment monitoring
• Provides practical guidance for studying cuproptosis using advanced in vitro and in vivo models, imaging techniques, and drug-screening technologies
• Integrates cutting-edge research with translational clinical insights