Wolfgang Beckmann is Senior Expert at Bayer Technologies. Dr. Beckmann studied Chemical Engineering and Physical Chemistry in Germany and the US. He spent one year as Postdoctoral Fellow in Marseille. Wolfgang Beckmann has spent the last 20 years working at Bayer and prior to this at Schering, developing crystallization processes for pharmaceutical compounds. He has authored several chapters in books and approximately 50 publications in reviewed journals.

• CRYSTALLIZATION: INTRODUCTION MECHANISMS OF CRYSTALLIZATION Crystal LatticeNucleation of CrystalsGrowth and Growth Rate of Crystals SOLUBILITY AND SOLUTION EQUILIBRIA IN CRYSTALLIZATION Phase Equilibria and Phase Diagrams: General Issues Melt Phase Diagrams Solution Equilibria AGGLOMERATION DURING CRYSTALLIZATION Mechanisms and Kinetics of AgglomerationParameters Influencing Agglomeration Agglomeration during Crystallization Mechanical Properties of Agglomerates POLYMORPHISM OF CRYSTALLINE SYSTEMS Introduction and Definitions Occurrence and Properties of Polymorphs and Solvates Thermodynamics of Polymorphs of Solid-State Forms Thermodynamics of HydratesExperimental Techniques to Elucidate Thermodynamics Formation of Various Polymorphs and Solid-State Forms-Polymorph ScreensSelection of Optimal Form for Development THE INFLUENCE OF ADDITIVES AND IMPURITIES ON CRYSTALLIZATION Influence of Additives and Impurities on Crystallization Influence of Impurities: Modeling Tailor-Made Additives Modeling the Influence of Solvents PURIFICATION BY CRYSTALLIZATION IntroductionMechanisms of Impurity Incorporation and Purification CHARACTERIZATION OF CRYSTALLINE PRODUCTSIntroduction Characterization of Intrinsic Properties of a Solid Characterization of Particle Shape and Size Powder Flow Properties In-Process Characterization BASICS OF INDUSTRIAL CRYSTALLIZATION FROM SOLUTIONGeneration of Supersaturation in a Crystallizer Mass and Population Balance for Growth from Suspension Operation of a Continuous Crystallizer: Basics Operation of a Batch Crystallizer: Basics DEVELOPMENT OF BATCH CRYSTALLIZATIONS Setting Goals Crystallization of Organic Moieties Generation of Supersaturation in Batch CrystallizationsInitiation of Crystallization -Nucleation Phase Seeded Batch Crystallizations Crystallization Period Scale-Up Considerations Manipulating Particle Shape CONTINUOUS CRYSTALLIZATION Concept and Design of Continuous Crystallizers Various Continuous Crystallizers Periphery Special Features of the Process Adjustment of Suspension Densities PRECIPITATIONPrecipitation from Solution by Mixing Two StreamsSemi-Batch Precipitations Model of Mixing during Precipitation Precipitations Using Supercritical FluidsCrystal IssuesParticle Size as a Function of Operating Conditions MIXING IN CRYSTALLIZATION PROCESSES Mixing in Batch and Continuous Crystallization Processes Basic Mixing Tasks - Mixing Tasks in Crystallization Impellers and Agitation SystemsPower Consumption of an Impeller System [2] Blending SuspendingScale-Up of a Crystallization Process DOWNSTREAM PROCESSES Transfer of Suspension and Filter CakeSolid?Liquid SeparationDrying MELT CRYSTALLIZATION Characteristics of Melt Crystallization Processes of Melt Crystallization Postcrystallization Treatments Laboratory Techniques EXAMPLES OF REALIZED CONTINUOUS CRYSTALLIZATION PROCESSES Choosing the Drain Point in Process Design Example Crop Crystallization for Organic CompoundsExample Crystallization of Table Salt Results DESIGN EXAMPLES OF MELT CRYSTALLIZATIONConcepts of Melt Crystallization Outlook INDEX

Select Guide Rating

Wolfgang Beckmann is Senior Expert at Bayer Technologies. Dr. Beckmann studied Chemical Engineering and Physical Chemistry in Germany and the US. He spent one year as Postdoctoral Fellow in Marseille. Wolfgang Beckmann has spent the last 20 years working at Bayer and prior to this at Schering, developing crystallization processes for pharmaceutical compounds. He has authored several chapters in books and approximately 50 publications in reviewed journals.

• CRYSTALLIZATION: INTRODUCTION MECHANISMS OF CRYSTALLIZATION Crystal LatticeNucleation of CrystalsGrowth and Growth Rate of Crystals SOLUBILITY AND SOLUTION EQUILIBRIA IN CRYSTALLIZATION Phase Equilibria and Phase Diagrams: General Issues Melt Phase Diagrams Solution Equilibria AGGLOMERATION DURING CRYSTALLIZATION Mechanisms and Kinetics of AgglomerationParameters Influencing Agglomeration Agglomeration during Crystallization Mechanical Properties of Agglomerates POLYMORPHISM OF CRYSTALLINE SYSTEMS Introduction and Definitions Occurrence and Properties of Polymorphs and Solvates Thermodynamics of Polymorphs of Solid-State Forms Thermodynamics of HydratesExperimental Techniques to Elucidate Thermodynamics Formation of Various Polymorphs and Solid-State Forms-Polymorph ScreensSelection of Optimal Form for Development THE INFLUENCE OF ADDITIVES AND IMPURITIES ON CRYSTALLIZATION Influence of Additives and Impurities on Crystallization Influence of Impurities: Modeling Tailor-Made Additives Modeling the Influence of Solvents PURIFICATION BY CRYSTALLIZATION IntroductionMechanisms of Impurity Incorporation and Purification CHARACTERIZATION OF CRYSTALLINE PRODUCTSIntroduction Characterization of Intrinsic Properties of a Solid Characterization of Particle Shape and Size Powder Flow Properties In-Process Characterization BASICS OF INDUSTRIAL CRYSTALLIZATION FROM SOLUTIONGeneration of Supersaturation in a Crystallizer Mass and Population Balance for Growth from Suspension Operation of a Continuous Crystallizer: Basics Operation of a Batch Crystallizer: Basics DEVELOPMENT OF BATCH CRYSTALLIZATIONS Setting Goals Crystallization of Organic Moieties Generation of Supersaturation in Batch CrystallizationsInitiation of Crystallization -Nucleation Phase Seeded Batch Crystallizations Crystallization Period Scale-Up Considerations Manipulating Particle Shape CONTINUOUS CRYSTALLIZATION Concept and Design of Continuous Crystallizers Various Continuous Crystallizers Periphery Special Features of the Process Adjustment of Suspension Densities PRECIPITATIONPrecipitation from Solution by Mixing Two StreamsSemi-Batch Precipitations Model of Mixing during Precipitation Precipitations Using Supercritical FluidsCrystal IssuesParticle Size as a Function of Operating Conditions MIXING IN CRYSTALLIZATION PROCESSES Mixing in Batch and Continuous Crystallization Processes Basic Mixing Tasks - Mixing Tasks in Crystallization Impellers and Agitation SystemsPower Consumption of an Impeller System [2] Blending SuspendingScale-Up of a Crystallization Process DOWNSTREAM PROCESSES Transfer of Suspension and Filter CakeSolid?Liquid SeparationDrying MELT CRYSTALLIZATION Characteristics of Melt Crystallization Processes of Melt Crystallization Postcrystallization Treatments Laboratory Techniques EXAMPLES OF REALIZED CONTINUOUS CRYSTALLIZATION PROCESSES Choosing the Drain Point in Process Design Example Crop Crystallization for Organic CompoundsExample Crystallization of Table Salt Results DESIGN EXAMPLES OF MELT CRYSTALLIZATIONConcepts of Melt Crystallization Outlook INDEX

Select Guide Rating

Wolfgang Beckmann is Senior Expert at Bayer Technologies. Dr. Beckmann studied Chemical Engineering and Physical Chemistry in Germany and the US. He spent one year as Postdoctoral Fellow in Marseille. Wolfgang Beckmann has spent the last 20 years working at Bayer and prior to this at Schering, developing crystallization processes for pharmaceutical compounds. He has authored several chapters in books and approximately 50 publications in reviewed journals.

• CRYSTALLIZATION: INTRODUCTION MECHANISMS OF CRYSTALLIZATION Crystal LatticeNucleation of CrystalsGrowth and Growth Rate of Crystals SOLUBILITY AND SOLUTION EQUILIBRIA IN CRYSTALLIZATION Phase Equilibria and Phase Diagrams: General Issues Melt Phase Diagrams Solution Equilibria AGGLOMERATION DURING CRYSTALLIZATION Mechanisms and Kinetics of AgglomerationParameters Influencing Agglomeration Agglomeration during Crystallization Mechanical Properties of Agglomerates POLYMORPHISM OF CRYSTALLINE SYSTEMS Introduction and Definitions Occurrence and Properties of Polymorphs and Solvates Thermodynamics of Polymorphs of Solid-State Forms Thermodynamics of HydratesExperimental Techniques to Elucidate Thermodynamics Formation of Various Polymorphs and Solid-State Forms-Polymorph ScreensSelection of Optimal Form for Development THE INFLUENCE OF ADDITIVES AND IMPURITIES ON CRYSTALLIZATION Influence of Additives and Impurities on Crystallization Influence of Impurities: Modeling Tailor-Made Additives Modeling the Influence of Solvents PURIFICATION BY CRYSTALLIZATION IntroductionMechanisms of Impurity Incorporation and Purification CHARACTERIZATION OF CRYSTALLINE PRODUCTSIntroduction Characterization of Intrinsic Properties of a Solid Characterization of Particle Shape and Size Powder Flow Properties In-Process Characterization BASICS OF INDUSTRIAL CRYSTALLIZATION FROM SOLUTIONGeneration of Supersaturation in a Crystallizer Mass and Population Balance for Growth from Suspension Operation of a Continuous Crystallizer: Basics Operation of a Batch Crystallizer: Basics DEVELOPMENT OF BATCH CRYSTALLIZATIONS Setting Goals Crystallization of Organic Moieties Generation of Supersaturation in Batch CrystallizationsInitiation of Crystallization -Nucleation Phase Seeded Batch Crystallizations Crystallization Period Scale-Up Considerations Manipulating Particle Shape CONTINUOUS CRYSTALLIZATION Concept and Design of Continuous Crystallizers Various Continuous Crystallizers Periphery Special Features of the Process Adjustment of Suspension Densities PRECIPITATIONPrecipitation from Solution by Mixing Two StreamsSemi-Batch Precipitations Model of Mixing during Precipitation Precipitations Using Supercritical FluidsCrystal IssuesParticle Size as a Function of Operating Conditions MIXING IN CRYSTALLIZATION PROCESSES Mixing in Batch and Continuous Crystallization Processes Basic Mixing Tasks - Mixing Tasks in Crystallization Impellers and Agitation SystemsPower Consumption of an Impeller System [2] Blending SuspendingScale-Up of a Crystallization Process DOWNSTREAM PROCESSES Transfer of Suspension and Filter CakeSolid?Liquid SeparationDrying MELT CRYSTALLIZATION Characteristics of Melt Crystallization Processes of Melt Crystallization Postcrystallization Treatments Laboratory Techniques EXAMPLES OF REALIZED CONTINUOUS CRYSTALLIZATION PROCESSES Choosing the Drain Point in Process Design Example Crop Crystallization for Organic CompoundsExample Crystallization of Table Salt Results DESIGN EXAMPLES OF MELT CRYSTALLIZATIONConcepts of Melt Crystallization Outlook INDEX

Select Guide Rating