Critical Issues in Head and Neck Oncology

Biomarkers in Head and Neck Squamous Cell Cancer (HNSCC).- Promising biomarkers for early diagnosis and prognosis prediction in HNS.- Biomarkers to predict radiotherapy toxicity.- Biomarkers for hypoxia, HPVness and proliferation from imaging perspective.- Mechanism of cetuximab resistance and how to overcome it.- The role of liquid biopsy for monitoring disease evolution.- NK cells in immunotherapy: how important are they?.- Biomarkers for immune modulatory treatment in HNSCC.- Primary disease (1).- Novel approaches in surgical management of HNSCC.- The surgical approach to elderly patients with HNSCC .- The nonsurgical approach to locoregionally advanced HNSCC.- High-dose three-weekly or low-dose weekly cisplatin during radiation, what to prefer?.- Primary disease (2).- Where and when to use induction chemotherapy?.- Prognostic role of p16/HPV in non-oropharyngeal head and neck cancer.- Is there a role for neoadjuvant targeted and immunotherapies?.- Is there a role for adjuvant targeted and immunotherapies? .- Optimal supportive measures during primary treatment.- Precision Medicine in head and neck cancer: myth or reality.- Recurrent and / or metastatic disease.- Salvage surgery:  candidates, safe reconstruction, and results?.-  Re-irradiation for local relapses or second primaries: when and how?.- New promising targeted agents in first and second-line settings.- Update of immune therapies in recurrent/metastatic HNSCC.- Special Issue.- Patients with rare head neck cancers: do they need a different approach? .-Nasopharynx cancer.- New epidemiological aspects.- New developments in the management of nasopharyngeal carcinoma.- New drugs for recurrent/metastatic nasopharynx cancer.