CRISPR-/Cas9 Based Genome Editing for Treating Genetic Disorders and Diseases

Luis María Vaschetto received his Doctorate in Biological Sciences from Universidad Nacional de Córdoba (Argentina). He was a postdoctoral researcher at the Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET) and a research associate at South Dakota State University (SDSU). His research focuses on understanding the epigenetic mechanisms involved in plant and animal development, as well as their effects on human health and diseases.

• 1. The CRISPR/Cas9 Genome-editing System: Principles and Applications 2. Recent Applications of CRISPR-Cas9 in Genome Mapping and Sequencing 3. Gene Editing and Genetic Disorders: Ethical and Legal Concerns 4. Political, Regulatory and Ethical Considerations of the CRISPR/Cas Genome Editing Technology 5. CRISPR/Cas and Gene Therapy: An Overview 6. CRISPR and Cancer: From Bench to Clinic 7. The Advances of the CRISPR/Cas9 Technology for Correcting Genetic Disorders: Using Sarcoma as a Model System 8. CRISPR/Cas9 Technology as a Strategy Against Viral Infections 9. CRISPR/Cas9-based Genome and Epigenome Editing in Neuroscience Research 10. Non-viral Alternatives to Delivery of CRISPR-Cas Gene Editing Components 11. CRISPR Medicine: Advance, Progress and Challenges

'Overall, this is an excellent book and a valuable contribution to the burgeoning field of human genome editing. Each chapter is well sourced and has an extensive list of references. Indeed, more than 25 percent of the 259 numberedpages in the book are devoted to references. This book offers an excellent starting point for exploration of genome editing in humans and is highly recommended.'- Mark F. Sanders, PhD, UC Davis College of Biological Sciences