CPP, Cell-Penetrating Peptides

Ülo Langel is a Professor Emeritus at the Department of Biochemistry and Biophysics, Stockholm University, and at the Institute of Technology, Tartu University. Prof. Langel graduated from Tartu University, Tartu, Estonia, as bioorganic chemist in 1974; he has received his PhD degree twice: in 1980 from Tartu University, Tartu, Estonia (bioorganic chemistry), and in 1993 from Tartu University/Stockholm University (biochemistry/neurochemistry). His professional experience includes a career at Tartu University, Tartu, Estonia (from junior research fellow to Associate Professor, Visiting Professor, and Professor 1974-now); The Scripps Research Institute, La Jolla, CA, USA (Associate Professor, and Adjunct Professor 2000-now); and Stockholm University (from research fellow to Associate Professor, Professor and Chairman, 1987-now). He is a Honorary Professor at Ljubljana University, Slovenia. He was a Chairman of the Board of small companies Pepfex (Stockholm) and Cepep (Estonia) and member of the Board of Orexo (Sweden). In 2013 he was elected a member of Academia Europaea and in 2015, a foreign member of the Estonian Academy of Sciences. Prof. Langel has been selected as a Fellow Member of International Neuropeptide Society (1995), and is a member of International Society for Neurochemistry, European Peptide Society, Swedish Biochemical Society and Estonian Biochemical Society.  He has been awarded a White Star Order, 4th class, by Estonian Republic. He has been invited lecturer at numerous international conferences, and is a coauthor of more than 480 scientific articles and 20 approved or pending patents. His research interest is in neurochemistry where his research is aimed to study peptides, particularly neuropeptide receptors, and in drug delivery by cell-penetrating peptides

• 1. Introduction.- 2. Classes and applications of CPP.- 3. CPP selection, prediction and in silico analysis.- 4. Labeling of CPPs.- 5. Methods for CPP functionalization with oligonucleotides.- 6. Additional (gene therapeutic) platforms.- 7. Protein delivery and mimicry.- 8. General targeting strategies.- 9. Targeting specific barriers.- 10. Methods for molecular imaging, detection and visualization of CPPs.- 11. Methods for structural studies of CPPs.- 12. Kinetics.- 13. Toxicity and immune response.- 14. Cell-translocation mechanisms of CPPs.- 15. Clinical trials and commercialization using CPPs.- 16. Therapeutic potential of CPPs.- 17. CPP functionalized nanoparticles.- 18. Concluding remarks.