Del i serien Cancer Drug Discovery and Development

COX-2 Blockade in Cancer Prevention and Therapy

Häftad, Engelska, 2010

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This book chronicles the evidence for the chemopreventive and therapeutic effects of cyclooxygenase-2 (COX-2) inhibitors against virtually all forms of cancer and presents exciting new opportunities for the use of COX-2 blockade in its prevention and treatment. The authors elucidate the process by which COX-2 inhibitors interrupt prostaglandin biosynthesis and cancer development, examine the positive epidemiological effects of such NSAIDs as aspirin and ibuprofen on various cancers, and demonstrate through animal models that COX-2 inhibitors and NSAIDs inhibit a variety of malignant neoplasms in vivo. They also present genetic models confirming the critical role of COX-2 in carcinogenesis and discuss how its molecular biology modulates carcinogenesis. In addition, the authors review the clinical applications of selected NSAIDs that are immediately relevant to cancer prevention and control and outline the future prospects of COX-2 blocking agents.

Produktinformation

Utgivningsdatum2010-11-19
Mått178 x 254 x 21 mm
Vikt721 g
FormatHäftad
SpråkEngelska
SerieCancer Drug Discovery and Development
Antal sidor371
FörlagHumana Press Inc.
ISBN9781617373046

Tillhör följande kategorier

Onkologi inom Medicin

I. Historical Perspectives.- l Dietary Fatty Acids, COX-2 Blockade, and Carcinogenesis.- 2 Historical Aspects of COX-2: Cloning and Characterization of the cDNA, Protein and Gene.- II. Epidemiology of NSAIDS and Cancer.- 3 Epidemiology of Nonsteroidal Anti-Inflammatory Drugs and Colorectal Cancer.- 4 Epidemiology of Breast Cancer and Nonsteroidal Anti-Inflammatory Drugs: Extension of the Dietary Fat Hypothesis of Breast Cancer.- III. Animal Models of Carcinogenesis.- 5 Role of Synthetic and Naturally Occurring Cyclooxygenase Inhibitors in Colon Cancer Prevention.- 6 Chemoprevention of Breast Cancer by Nonsteroidal Anti-Inflammatory Drugs and Selective COX-2 Blockade in Animals.- 7 The Role of Cyclooxygenase-2 in the Prevention and Therapy of Lung Cancer.- 8 Nonsteroidal Anti-Inflammatory Drugs, Prostaglandins, and Apc-Driven Intestinal Tumorigenesis.- 9 Cyclooxygenase-1 and Cyclooxygenase-2 Knockout Mice Provide Insights into Beneficial and Adverse Effects of Nonsteroidal Anti-Inflammatory Drugs.- IV. Molecular Biology of CXO.- 10 Cyclooxygenase-2, Prostaglandins, and Colorectal Carcinogenesis.- 11 Regulation of Expression and Potential Carcinogenic Role of Cyclooxygenase-2.- 12 Cyclooxygenase-2 and Cancer.- 13 Interactions of Cyclooxygenase and Aromatase Pathways in Normal and Malignant Breast Cells.- 14 Association of COX-2 and PPARs in Carcinogenesis and Chemoprevention.- 15 Carcinogenesis Involving Cyclooxygenase and Lipoxygenase.- V. Clinical Applications.- 16 The Development of Drugs that Target Cyclooxygenase-2.- 17 Chemoprevention of Cancer by NSAIDs and Selective COX-2 Blockade.- 18 Potential for Inhibitors of Cyclooxygenase-2 to Enhance Tumor Radioresponse.- 19 Potential Role of NSAIDs and COX-2 Blockade in Cancer Therapy.- 20 Cyclooxygenase-2 Blockade in Cancer Prevention and Therapy: Widening the Scope of Impact.

"...a must, not only for oncologists but also for every family doctor, who is often the first to see a patient with a cancerous or precancerous or precancerous condition." -Lancet Oncology "This comprehensive and up-to-date monograph demonstrates how COX-2 inhibitors and other NSaids reduce the risk of most cancers and provides cancer investigators by a clear and authoritative guide leading to the development of novel angst with significant antineoplastic properties." -Neoplasma