In this issue of�Infectious Disease Clinics of North America,�guest�editors�Drs.�Rachel Bender Ignacio and Rajesh T. Gandhi�bring�their�considerable expertise to the topic of�COVID-19 Infection.�The evolving virology, wide range of symptoms, long-term health issues, mortality rate, effect on hospitals, and high transmission rate have made�COVID-19 one of the worst health crises in recent times.�In this issue, top experts in the field address key issues such as diagnostic testing, COVID-19 in pediatrics, post-acute sequelae, infection control, and much more,�aiming to arm clinicians with the information they need to combat this deadly infection.