Contemporary Practice in Clinical Chemistry

Dr. William Clarke is a Professor of Pathology at the Johns Hopkins University School of Medicine. His research focuses on the development of analytical methods for drug analysis, clinical mass spectrometry, and devices for point-of-care testing. He serves as the director of Clinical Toxicology for Johns Hopkins Hospital, as well as the Point-of-Care Testing Program for Johns Hopkins Medicine. Dr. Mark Marzinke is Associate Professor of Pathology and Medicine at the Johns Hopkins University School of Medicine.Dr. Marzinke serves as the Director of General Chemistry in the Johns Hopkins Hospital Core Laboratories, and is the Director of the Clinical Pharmacology Analytical Laboratory within the Division of Clinical Pharmacology. He is also Co-Director of the HIV Prevention Trials Network Laboratory Center.

• Part I: Preanalytical and Analytical Foundations1. Preanalytical Variation2. Statistical Methods in Laboratory Medicine3. Reference Intervals4. Method Evaluation5. Quality Control6. Laboratory CalculationsPart II: Instrumentation and Techniques7. Spectrophotometry8. Chromatography and Electrophoresis9. Electrochemistry10. Mass Spectrometry11. Nuclear Magnetic Resonance (NMR)12. Immunoassays13. PCR and Nucleic Acid Probes14. Laboratory Automation and Specimen ManagementPart III: Laboratory Management and Informatics15. Regulatory Issues16. Evidence-Based Laboratory Medicine17. Standardization and Harmonization in Laboratory Medicine18. Laboratory Information Systems19. Point-of-Care TestingPart IV: Molecular and Proteomic Applications20. Applications of Molecular Techniques in Laboratory Medicine21. Applications of Mass Spectrometry/Proteomics22. Proteins: Analysis and Interpretation in Serum, Urine, and CSF23. Complement SystemPart V: Hematology and Coagulation24. Hemoglobinopathies: Biochemical Disorders of Hemoglobin HemostasisPart VI: Specialized Testing and Alternative Matrices25. Testing in Alternative Matrices: CSF and Body Fluid Analysis26. Lipoprotein Disorders27. Testing in the Neonate/Pediatric TestingPart VII: Organ System Disorders and Biomarkers28. Biomarkers for Coronary Artery Disease and Heart Failure29. Laboratory Diagnosis of Liver Disease30. Gastrointestinal Disorders31. Laboratory Evaluation of the Pancreas32. Carbohydrate Disorders33. Laboratory Evaluation of Kidney Function34. Blood Gas and Critical Care Testing35. Water and Electrolyte Balance UrinalysisPart VIII: Endocrinology and Reproductive Testing36. Disorders of the Anterior and Posterior Pituitary37. Laboratory Evaluation of Thyroid Function38. Disorders of the Adrenal Cortex and Medulla39. Laboratory Testing in Pregnancy40. Lab Testing in Reproductive DisordersPart IX: Oncology and Nutritional Testing41. Tumor Markers42. Calcium Biology and Disorders43. Vitamins and Nutritional Testing44. Trace ElementsPart X: Metabolic and Pharmacologic Testing45. Inborn Errors of Metabolism and Newborn Screening46. Porphyrias47. Pharmacokinetics48. Therapeutic Drug Monitoring49. Toxicology and the Clinical Laboratory50. PharmacogenomicsPart XI: Infectious Diseases and Microbiology51. Infectious Diseases52. Clinical MicrobiologyPart XII: Informatics and Laboratory Practice53. Bioinformatics and Artificial Intelligence54. Laboratory Stewardship55. Biomarkers for Neurodegenerative Disease56. Clinical Decision Support