Concepts and Models for Drug Permeability Studies

Cell and Tissue based In Vitro Culture Models

Inbunden, Engelska, 2015

Av Bruno Sarmento

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This book intends to be an updated compilation of the most important buccal, gastric, intestinal, pulmonary, nasal, vaginal, ocular, skin and blood-brain barrier in vitro models for predicting the permeability of drugs. Concepts and Models for Drug Permeability Studies focuses on different approaches and comprises of various models. Each model describes the protocol of seeding and conservation, the application for specific drugs, and takes into account the maintenance of physiologic characteristics and functionality of epithelium, from the simplest immortalized cell-based monoculture to the most complex engineered-tissue models. Chapters also discuss the equivalence between in vitro cell and tissue models and in vivo conditions, highlighting how each model may provisionally resemble a different drug absorption route.

Updated information regarding the most recent in vitro models to study the permeability of drugs
Short and concise chapters covering all the biological barriers with interest in drug permeability
A�combination of bibliographic information related with individual models and footnote instructions of technical procedures for construction of cell and tissue-based models
Simple and clear scientific content, adaptable for young scientists and experimented researchers

Produktinformation

Utgivningsdatum2015-10-08
Mått152 x 229 x undefined mm
Vikt550 g
FormatInbunden
SpråkEngelska
Antal sidor408
FörlagElsevier Science
ISBN9780081000946

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Farmakologi inom Medicin

BBruno Sarmento is Principal Investigator and Group Leader at Institute for Research and Innovation in Health (i3S), University of Porto (UP), and Invited Associate Professor at Instituto Universitário de Ciências da Saúde (IUCS), Portugal. His research is focused on the development of mucosal tissue engineering models to validate functionalized nanomedicines and to perform in vitro/in vivo correlation. He has also established functionalized nanomedicines for mucosal drug delivery of drug with poor mucosal bioavailability. He published more than 400 papers in international journals, most in top journals (20000 Scopus citations; H-index 73). He edited 5 books, participated in more than 50 invited/selected talks in national and international meetings and was awarded several distinctions. He has supervised/co-supervised 15 Post-Docs, 50 PhD students and 40 MSc students. He is editor of European Journal of Pharmaceutical Sciences, and member of the Editorial Advisory Board of several international journals, including the Journal of Controlled Release, Expert Opinion on Drug Delivery and Pharmaceutics. Bruno Sarmento was the first Chair of the Nanomedicine and Nanoscale Delivery Focus Group of the Controlled Release Society (CRS) and is now Director-at-Large of CRS and member of CRS College of Fellows.

1. Introduction2. Importance and applications of cell and tissue-based in vitro models for drug permeability screening in early stages of drug development3. Immortalized cell-based in vitro culture models for drug permeability studies4. Primary isolated cell-based in vitro culture models for drug permeability studies5. Tissue-based in vitro culture models for drug permeability studies6. Correlation between cell and tissue-based in vitro models for drug permeability screening with in vivo situation: Modeling and functional extrapolation