This book constitutes the refereed proceedings of the 18th Annual ACM India Compute Conference on COMPUTE 2025, held in Ropar, India, during December 7–9, 2025.The 12 full papers and 5 short papers included in this book were carefully reviewed and selected from 79 submissions. They were organized in topical sections as follows: AI and Responsible Computing in Education; Pedagogical Innovations and Interdisciplinary Approaches; Accessibility, Inclusion, and Equity in CS Education; and Tools and Interventions for Core Computing Concepts.