Computer-Aided Vaccine Design

Dr Joo Chuan Tong is a Senior Scientist at the A*STAR Institute of High Performance Computing, Singapore. He is an Adjunct Assistant Professor at the Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore. Dr. Tong has won numerous awards, including the MIT TR35 Award in 2008 and Singapore Youth Award (Science and Technology) in 2009, and is the only Asian on the Senior Innovation Advisory Board of Pfizer Inc, the world’s largest research-based pharmaceutical company, at their world headquarters in New York, USA.

• List of figuresList of abbreviationsAbout the authorsPrefaceChapter 1: MHC and T cell responsesAbstract:1.1 Genetic organization of the MHC1.2 MHC structure1.3 MHC function1.4 Peptide bindingChapter 2: Immunoglobulins and B cell responsesAbstract:2.1 Types of immunoglobulins2.2 Immunoglobulin structure2.3 Immunoglobulin function2.4 Antigen bindingChapter 3: Scientific publications and databasesAbstract:3.1 Bibliographical information3.2 Searching the literature3.3 General databases containing information on genes and proteins3.4 Immunological databases3.5 Small molecule databasesChapter 4: Database designAbstract:4.1 Fundamentals of database design4.2 ER diagram4.3 Normalization and normal formsChapter 5: Computational T cell vaccine designAbstract:5.1 Sequence-based methods5.2 Structure-based methods5.3 Broad-based T cell vaccine designChapter 6: Computational B cell vaccine designAbstract:6.1 Sequence-based methods6.2 Structure-based methodsChapter 7: Infectious disease informaticsAbstract:7.1 Infectious diseases in history7.2 Microbial sequence analysis7.3 Detecting natural selection in molecular evolutionChapter 8: Vaccine safety and quality assessmentsAbstract:8.1 Assessment of ADME/Tox deficiencies8.2 Assessment of allergenicityChapter 9: Vaccine adjuvant informaticsAbstract:9.1 Virtual combinatorial library9.2 Chemical file formats9.3 Considerations for virtual library designIndex