This CCIS book constitutes selected papers accepted in the Research Track on Computational Science and the Research Track on Computational Intelligence held as part of the 11th International Conference on Computational Science and Computational Intelligence, CSCI 2024, which took place in Las Vegas, NV, USA, during December 11–13, 2024.The 24 full papers included in this book were carefully reviewed and selected from a total of 78 submissions.The Research Track on Computational Science, CSCI-RTSC, received 78 submissions of which 17 papers were accepted; 16 of these are included in this volume. For the Research Track on Computational Intelligence, CSCI-RTCI, 10 papers were accepted from 59 submissions. The contributions were organized in topical sections on Computational Science - Frameworks, Applications, and Algorithms; Computational Science - Mathematics, Simulation, Performance Studies, Optimization and Programming; and Computational Intelligence - Optimization, Applications and Algorithms.