This book constitutes the refereed proceedings of the 6th IFIP TC 5 International Conference on Computational Intelligence and Its Applications, CIIA 2018, held in Oran, Algeria, in May 2018.The 56 full papers presented were carefully reviewed and selected from 202 submissions. They are organized in the following topical sections: data mining and information retrieval; evolutionary computation; machine learning; optimization; planning and scheduling; wireless communication and mobile computing; Internet of Things (IoT) and decision support systems; pattern recognition and image processing; and semantic web services.