Del 0 - Methods in Molecular Biology

Computational Design of Ligand Binding Proteins

Häftad, Engelska, 2018

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This volume provides acollection of protocols and approaches for the creation of novel ligand bindingproteins, compiled and described by many of today's leaders in the field ofprotein engineering.

Produktinformation

Utgivningsdatum2018-04-21
Mått178 x 254 x 22 mm
Vikt735 g
FormatHäftad
SpråkEngelska
SerieMethods in Molecular Biology
Antal sidor375
FörlagHumana Press Inc.
ISBN9781493980802

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In silico Identification and Characterization of Protein-Ligand BindingSites.- Computational Modeling of Small Molecule Ligand Binding Interactionsand Affinities.- Binding Site Prediction of Proteins with Organic Compounds orPeptides Using GALAXY Web Servers.- Rosetta and the Design of Ligand Binding Sites.-PocketOptimizer and the Design of Ligand Binding Sites.- Proteus and the Designof Ligand Binding Sites.- A Structure Based Design Protocol for OptimizingCombinatorial Protein Libraries.- Combined and Iterative Use of ComputationalDesign and Directed Evolution for Protein-Ligand Binding Design.- ImprovingBinding Affinity and Selectivity of Computationally Designed Ligand BindingProteins Using Experiments.- Computational Design of MultinuclearMetalloproteins Using Unnatural Amino Acids.- De Novo Design ofMetalloproteins and Metalloenzymes in a Three-helix Bundle.- Design ofLight-Controlled Protein Conformations and Functions.- ComputationalIntroduction of Catalytic Activity into Proteins.- Generating High AccuracyPeptide Binding Data in High Throughput with Yeast Surface Display andSORTCERY.- Design of Specific Peptide-Protein Recognition.- Computational Designof DNA-binding Proteins.- Motif-driven Design of Protein-Protein Interfaces.- ComputationalReprogramming of T Cell Antigen Receptor Binding Properties.- ComputationalModeling of T Cell Receptor Complexes.- Computational Design of ProteinLinkers.- Modeling of Protein-RNA Complex Structures Using ComputationalDocking Methods.