In this issue of Clinics in Liver Disease, guest editor Dr. James P. Hamilton brings his considerable expertise to the topic of Complications of Cirrhosis. As the burden of liver disease continues to rise-driven by increasing rates of alcohol use disorder, obesity, and diabetes-it is critical that providers across specialties stay informed about the evolving landscape of complications. In this issue, top experts review key topics covering the major complications of advanced liver disease and cirrhosis.