This book contains all refereed papers thatwere accepted to the second edition of the Asia-Pacific conference on « ComplexSystems Design & Management Asia» (CSD&M Asia 2016) that tookplace in Singapore from February 24  toFebruary 26, 2016 (Website: http://www.2016.csdm-asia.net/).These proceedings cover the most recent trendsin the emerging field of Complex Systems, both from an academic and aprofessional perspective. A special focus is put on Smart Nations: Designingand Sustaining. The CSD&M Asia 2016 conference is organizedunder the guidance of the Singapore division of the Center of Excellence onSystems Architecture, Management, Economy and Strategy (CESAMES) – Legal address:C.E.S.A.M.E.S. Singapore – 16 Raffles Quay – #38-03 Hong Leong Building –Singapore 048581 (website : http://www.cesames.net/en– email: contact@cesames.net).