Comparative Genomics and Proteomics in Drug Discovery

John Parrington and Kevin Coward, Department of Pharmacology, University of Oxford, UK.

• 1. Comparative Genomics and Drug Discovery in Trypanosomatids  2. The Practical Implications of Comparative Kinetoplastid Genomics  3. The Relevance of Host Genes in Malaria  4. Nicotinic Acetylcholine Receptors as Drug/Chemical Targets, Contributions from Comparative Genomics, Forward and Reverse Genetics  5. Discovery of Novel Sodium Channel Inhibitors - A Gene Family-Based Approach  6. 'Omics' in Translational Medicine : Are They Lost in Translation?  7. Drug-Target Discovery In Silico : Using the Web to Identify Novel Molecular Targets for Drug Action