Del 20 - Computational Biology

Comparative Gene Finding

Models, Algorithms and Implementation

Inbunden, Engelska, 2015

AvMarina Axelson-Fisk

1 369 kr

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This book presents a guide to building computational gene finders, and describes the state of the art in computational gene finding methods, with a focus on comparative approaches. Fully updated and expanded, this new edition examines next-generation sequencing (NGS) technology. The book also discusses conditional random fields, enhancing the broad coverage of topics spanning probability theory, statistics, information theory, optimization theory and numerical analysis. Features: introduces the fundamental terms and concepts in the field; discusses algorithms for single-species gene finding, and approaches to pairwise and multiple sequence alignments, then describes how the strengths in both areas can be combined to improve the accuracy of gene finding; explores the gene features most commonly captured by a computational gene model, and explains the basics of parameter training; illustrates how to implement a comparative gene finder; examines NGS techniques and how to build a genome annotation pipeline.

Produktinformation

Utgivningsdatum2015-04-22
Mått155 x 235 x 28 mm
Vikt770 g
FormatInbunden
SpråkEngelska
SerieComputational Biology
Antal sidor382
Upplaga2
FörlagSpringer London Ltd
ISBN9781447166924

Tillhör följande kategorier

Biologi inom Naturvetenskap och teknik
Biovetenskap inom Naturvetenskap och teknik
Biokemi inom Naturvetenskap och teknik

“The structure of the book mirrors the learning steps for understanding how to perform gene finding. … Its target audience is mainly post-graduate researchers or established researchers with a background in mathematics or statistics applied in bioinformatics who need a thorough yet concise overview of this field.” (Irina Ioana Mohorianu, zbMATH 1350.92001, 2017)“It skillfully introduces readers to a difficult subject, while at the same time motivating them to enter this very important area. … It is best suited for a graduate course or as an introduction for researchers not familiar with this field. … this is an excellent introduction to comparative gene finding. … I especially recommend this book to any computer scientist with an interest in current problems in bioinformatics.” (Burkhard Englert, Computing Reviews, December, 2015)