Comorbidities and Social Complications of Epilepsy and Seizures

Arjune is a Consultant Epileptologist, Senior Fellow in Epileptology and Head of the Oxford Epilepsy Research Group. He has a very busy epilepsy practice and has pioneered novel clinical pathways, including the development of specialist multidisciplinary clinics such as 'Epilepsy and learning disability' and 'Epilepsy and employment'.At a research level, Arjune has a broad portfolio of studies including autoimmune epilepsy and epilepsy genomics. His personal work is wholly multidisciplinary and integrates across three main areas - intersection of epilepsy and dementia; developing novel technologies to close diagnostic and treatment gaps; and implementation of culturally specific tools at scale. This applies as much in underprivileged settings as in the UK.Arjune is very interested in guideline development to ensure optimal care is attained worldwide. He served as Topic Advisor to the NICE Epilepsy Guidelines, 2022; has been appointed to the ILAE Standards and Best Practices Council.Professor Brown is registered specialist in Occupational Health Medicine and Toxicology and has undertaken clinical and advisory work on the comorbidities of epilepsy for more than 30 years. He is particularly interested in the interaction between epilepsy, work, study, memory, and cognition. Professor Brown has also undertaken research into the societal impacts of chronic pain and has accepted a regulatory role as a Responsible Officer for a Ministry of Defence medical service. His interests have now broadened to embrace the relationships between diet, health and neurological disorders and he will be working with the University of Reading and Oxford on dietary aspects of epilepsy and Alzheimer's disease, especially the role of ketogenesis and neuroinflammation.

• 1 Background to epilepsy and co-morbidity 1: Frank Besag and Michael Vasey: Introduction 2: Sameer M Zuberi: A practical classification of epilepsy with regards to co-morbidity 2 The impact of medical and surgical treatment on co-morbidity in patients with epilepsy 3: F J Rugg-Gunn and P N Patsalos: The effects of antiseizure medications on co-morbidities 4: Vejay N. Vakharia and Robert M. Brownstone: The impact of surgery on co-morbidities in epilepsy 3 Cognitive, Psychological and Systemic co-morbidity 5: Chris Butler: Epilepsy and cognition 6: Marco Mula, Dale C Hesdorffer, Michael R Trimble: Epilepsy and psychopathological co-morbidities 7: Tim Andrews and Rohit Shankar: Epilepsy and learning difficulties 8: Patricia Dugan: Epilepsy and systemic disease 9: Rohit Shankar, Lance Watkins, Samantha Ashby, Jane Hanna: Epilepsy and mortality 4 Epilepsy related co-morbidity in special groups 10: Emma Torzillo, Arjune Sen, Steven Schachter: Epilepsy and co-morbidity in later life 11: John Craig, Michael Kinney: Teratogenic risk and aspects of epilepsy relating to women> 's health V The psychosocial impact of epilepsy 12: Ian Brown: Epilepsy and the impact on study, learning and memory 13: Ian Brown: Epilepsy, employment and work 14: Ernest Somerville: Epilepsy and driving 15: Neha Kinariwalla and Arjune Sen: Epilepsy, marriage and other social relationships

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