Del 26 i serien Methods & Principles in Medicinal Chemistry

Combinatorial Chemistry

From Theory to Application

Inbunden, Engelska, 2006

AvSeries Editor:Raimund Mannhold,Series Editor:Hug Kubinyi,Willi Bannwarth,Berthold Hinzen

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The new edition of this practice-oriented handbook features thoroughly updated contents, including recent developments in parallel synthesis.A new chapter on screening complements the overview of combinatorial strategy and synthetic methods. "Experimental details and complete reaction data [...] are a constant theme running through this work"(Angewandte Chemie) "Recommended to newcomers in the field of combinatorial chemical synthesis because of its broad scope"(Journal of the American Chemical Society)

Produktinformation

Utgivningsdatum2006-04-04
Mått179 x 246 x 38 mm
Vikt1 411 g
FormatInbunden
SpråkEngelska
SerieMethods & Principles in Medicinal Chemistry
Antal sidor694
Upplaga2
FörlagWiley-VCH Verlag GmbH
ISBN9783527306930

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Willi Bannwarth is full Professor for Organic Chemistry at the Albert-Ludwigs University Freiburg (Germany). Having studied Chemistry in Münster and Konstanz, he worked as a postdoctoral fellow with Sir A. Battersby in Cambridge (UK). In 1979, he joined Roche in Basel (Switzerland) where he was head of nucleotide and peptide chemistry and later was named head of combinatorial chemistry, a technique which he had introduced at Roche. In 1996 he moved to Byk Gulden Pharmaceuticals (now Altanapharma) in Konstanz to build a cominatorial chemistry facility there. In 1999 he was appointed professor for Organic chemistry at the University of Freiburg where he focuses on combinatorial and bioorganic chemistry.

Purification Principles in High-Speed Solution Phase Synthesis(S. Weinbrenner, C. Tzschucke)Linkers for Solid-Phase Organic Synthesis (SPOS) and Combinatorial Approaches on Solid Support(W. Bannwarth)Cyclative Cleavage -A Versatile Concept in Solid-Phase Organic Chemistry(J. Pernerstorfer)C-C Bond Forming Reactions(W. Brill, G. Papeo)Combinatorial Synthesis of Heterocycles(E. Felder, A. Marzinzik)Polymer-Supported Reagents: Preparation and Use in Parallel Organic Synthesis(B. Hinzen, M. Hahn)Encoding Strategies for Combinatorial Libraries(B. Hinzen)Automation and Devices for Combinatorial Chemistry and Parallel Organic Synthesis(C. Zechel)Computer-Assisted Library Design(A. Dominik)Assays for High Throughput Screening in Drug Discovery(C. Apfel, T. Enderle)Appendix: Cheminformatics and Web Resources for Combinatorial Chemistry

"…this well-presented book provides a guide for the practicing organic chemist to readily implement a combinatorial approach." (CHOICE, January 2007) "This volume is an excellent addition to the series, and it will become a standard reference text for chemists, particularly those involved in drug discovery." (Journal of Medicinal Chemistry, December 28, 2006)"…the reviewer recommends this book to anyone who is interested in combinatorial chemistry or in the screening of small molecules in drug discovery." (Synthesis, September 2006)