This book constitutes the refereed proceedings of the 6th EAI International Conference on Cognitive Computing and Cyber Physical Systems, IC4S 2025, held in Andhra Pradesh, India, during December 15-17, 2025.The 27 full papers included in this book were carefully reviewed and selected from 110 submissions. They were categorized under the topical sections as follows: Signal Processing; Medical Diagnostics and Healthcare; AI-Enabled Technologies; AI and IoT Advance Applications; Computing Techniques; and Applications of Cyber-Physical Systems.
Signal Processing.- Analysis of Novel Edge Detection Technique using Adaptive Hybrid Model.- HOKMEM-QLDE: Ml Based Clustering and Routing Mechanism using for Wireless Sensor Networks.- Compressed Signal Reconstruction in Low-Power IoT Networks: A Comparative Study.- Hybrid Noise Reduction Technique for Sensor Data: A Wavelet Transform and Kalman Filtering Approach.- Hybrid2D: A User-Interactive Diffusion-Transformer Framework for Realistic 2D Portrait Animation on Tablets.- Medical Diagnostics and Healthcare.- Early Prediction of Alzheimer’s Disease using Image Segmentation and Regression Models.- Design of a Multimodal TENS Unit for Enhanced Physiotherapy Applications.- Lumber spine degeneration classification using MRI images with deep learning techniques.- A Fog-Based Framework PRISM for Multimodal Preprocessing in Adaptive Health Analytics.- AI-Enabled Technologies.- AI-Driven Diagnostic Framework for Early Gastric Carcinoma Detection.- Smart Image Cleanup Tool: An AI-Driven Solution for Efficient Image Management.- H-FRND: Hierarchical Fog-Based Rogue Node Detection Framework for VANET.- Performance Evaluation of DNN Embedding–based Speaker Identification System.- AI and IoT Advance Applications.- Sustainable AI-Enabled Supply Chain Architecture for Enhanced Communication and Decision Intelligence.- AI-Powered Knowledge Management System Using RAG for Multi-PDF Insights.- Next-Gen Library Services Using IoT for Enhanced User Experiences.- Integrated Smart Healthcare System with Automated Dispenser and Medical Chatbot.- Computing Techniques.- Scaling Behaviour of Quantum Feature Maps: Variance, Stability, and Hybrid QML Performance Under Qubit Growth.- AC Performance Analysis of Spacer Tuned NSFET for High Frequency Applications.- Multimodal Wireless Stethoscope with ESP32-C6 for Synchronized Acoustic and Bioelectrical Signal Acquisition in Cardiopulmonary Diagnostics.- Agent-based environment monitoring System withMicroservices and Edge Computing for Agriculture and Aquaculture.- Blockchain-Based Supply Chain Management for the Silk Industry.- Carbon Aware Task Scheduling in Edge Computing.- Applications of Cyber-Physical Systems.- Through the Fog: Unmasking Environmental, Safety, and Health Risks.- Next-Generation SRAM Architectures: 11T and Memristor-Driven Design Simulation.- Enhancing Healthcare Automation: An IoT Enabled Bluetooth-Based Smart Rover for Elderly Support.- Recent Advances in Gesture and Sign Language Recognition: A Methodological Review.