Clostridial Diseases of Animals

The editors Francisco A. Uzal, DVM, FRVC, MSc, PhD, Dipl. ACVP, is a Distinguished Professor of Diagnostic Pathology and Branch Chief of the San Bernardino Laboratory of the California Animal Health and Food Safety at the University of California at Davis in Davis, California, USA. Bruce A. McClane, PhD, FAAM, is a Professor of Microbiology and Molecular Genetics at the University of Pittsburgh School of Medicine in Pittsburgh, Pennsylvania, United States. Iman Mehdizadeh Gohari, DVM, MSc, PhD, is a Research Assistant Professor at the Department of Microbiology and Molecular Genetics at the University of Pittsburgh School of Medicine in Pittsburgh, Pennsylvania, United States. Mauricio A. Navarro, DVM, MSc, PhD, Dipl. ACVP, is an Assistant Professor of Veterinary Anatomic Pathology at the Universidad Austral de Chile in Valdivia, Chile. Michel R. Popoff, DVM, PhD, is a former Associate Professor and Head of the Research Unit of Anaerobic Bacteria and Toxins and the National Reference Center for Anaerobic Bacteria and Botulism at the Institut Pasteur in Paris, France.

• List of contributors xixPreface xxiiiPart I The pathogenic clostridia 11 Taxonomic relationships among the clostridia 3Paul A. Lawson2 General physiological and virulence properties of the pathogenic clostridia 9Julian I. Rood3 Brief description of animal pathogenic clostridia 15Iman Mehdizadeh GohariPart II Toxins produced by the pathogenic clostridia 254 Toxins of histotoxic clostridia: Clostridium chauvoei, Clostridium septicum, Clostridium novyi, Paraclostridium sordellii, Clostridium histolyticum 27Michel R. Popoff5 Toxins of Clostridium perfringens 67James R. Theoret, Iman Mehdizadeh Gohari, and Bruce A. McClane6 Toxins of Clostridioides difficile 83Panagiotis Papatheodorou7 Clostridium botulinum and Clostridium tetani neurotoxins 95Michel R. PopoffPart III Clostridial infections of the gastrointestinal system 1638 Diseases produced by Clostridium perfringens type A in animals 165Francisco A. Uzal and Mauricio A. Navarro9 Infections by Clostridium perfringens type B 175Francisco A. Uzal and John S. Munday10 Diseases produced by clostridium perfringens type c 183Santiago S. Diab and Horst Posthaus11 diseases produced by Clostridium perfringens type d 199Francisco A. Uzal, Federico Giannitti, John W. Finnie, and Jorge P. García12 Diseases produced by Clostridium perfringens type E 219Mauricio A. Navarro and Francisco A. Uzal13 Clostridium perfringens type F infections of animals 223Iman Mehdizadeh Gohari and Bruce A. McClane14 Diseases produced by Clostridium perfringens type G 231Kerry K. Cooper and Margarethe A. Cooper15 Diseases produced by Clostridioides difficile 267Santiago S. Diab and Francisco A. Uzal16 Disease caused by Clostridium colinum: ulcerative enteritis of poultry and other avian species 291Agustin Rebollada-Merino and Francisco A. Uzal17 Diseases produced by Thomasclavelia spiroformis 301Laura M. Tuomisto and Francisco A. Uzal18 Clostridial abomasitis 309John F. Prescott and Russell S. FraserPart IV Clostridial histotoxic infections 32519 Blackleg 327Camila C. Abreu and Francisco A. Uzal20 Gas gangrene 345Rodrigo O. S. Silva, Francisco A. Uzal, Carlos A. Oliveira Junior, and Francisco C. F. Lobato21 Gangrenous dermatitis in poultry 359Mauricio A. Navarro, Francisco A. Uzal, and H. L. Shivaprasad22 Bacillary hemoglobinuria 369Mauricio A. Navarro, Fernando Dutra-Quintela, and Francisco A. Uzal23 Infectious necrotic hepatitis 381Mauricio A. Navarro and Francisco A. Uzal24 Tyzzer disease 387Karina C. Fresneda, Juan A. García, and Francisco R. Carvallo-ChaigneauPart V Clostridial neurotoxic infections 40125 Tetanus 403Michel R. Popoff and Francisco A. Uzal26 Botulism 415Caroline Le Maréchal, Fabrizio Anniballi, Luca Bano, Martin B. Dorner, Miriam Koene, Christelle Mazuet, Christian Seyboldt, and Tom Van Nieuwenhuysen27 Diseases caused by other clostridia producing neurotoxins 451John F. Prescott and Michel R. PopoffPart VI Animal clostridial diseases as zoonosis and animals as reservoir of human clostridial pathogens 45528 Clostridial infections and one health 457Francisco A. Uzal and Michel R. PopoffIndex 475