"This much needed book is a gem. If you are involved in a clinical trial make sure you and all your collaborators have read it, before the trial commences...This book provides the information the clinician needs to understand how trials are organised, how data are collected, how they are analysed, and how their clinical significance should be assessed. Dr Guiloff has assembled an impressive team of contributors, all with expertise and experience in their subject. "The consistent high quality of [the] chapters is remarkable in a multiauthored text and a tribute to the hard work of the editor. The book concludes with a review by Michael Brooke that should be required reading for every neurologist. This book not only fills a gap on the neurologist's bookshelf but also will be opened again and again" -Michael Swash