Clinical Research Made Easy

Mohit Bhandari MD MSc PhD FRCSCCanada Research Chair in Musculoskeletal Trauma and Surgical Outcomes, Professor, Department of Surgery, Associate Member, Department of Health Research Methods, Evidence and Impact, Academic Division Head, Orthopaedic Surgery, McMaster University, Hamilton, USA Parag Kantilal Sancheti FRCS MS DNB MCh Professor and Chairman, Sancheti Institute for Orthopaedics and Rehabilitation, Pune, Maharashtra, India

• Section 1: The BasicsThe Origins of Evidence-based MedicineWhy do We Need Evidence-based MedicineTips to becoming an Evidence-based ClinicianQuality of Evidence—has it Improved? Section 2: Choosing the Right Study DesignLevels of Evidence—A Quick GuideLevel 1 Evidence—Randomized Controlled TrialsLevel 2 Evidence—Prospective Cohort StudiesLevel 3 Evidence—Case-control StudiesLevel 4 Evidence—Clinical Case SeriesLevel 5 Evidence—Surveys Section 3: Special Designs and TopicsThe Basics of Systematic Reviews and Meta-analysisThe Basics of Economic EvaluationThe Basics of a Diagnostic Test StudyThe Basics of ReliabilityQuick Guide to Assess Risk of Bias in Randomized Controlled TrialsGRADE—Understanding Grades of Healthcare Recommendations Section 4: The Research ProtocolFirst Things First—The Research ProposalChoosing the Outcome—A PrimerCommon Quality of Life and Health Utility Outcome ToolsAn Introduction to Sample SizeEstimating an Appropriate Sample Size—Advanced Concepts, Formulae and ExamplesPlanning your Analysis—Keep it SimpleWhat are Subgroup Analyses and How Should You Interpret Them? Section 5: Doing ResearchStudy Roles—Who does What?Research Ethics Approval—A must Before any Clinical TrialWhy do we Need Patient Consent? Designing a Good Consent FormCollecting Data—It all Begins with a Good Data Form Section 6: Getting the Word Out— Presentation and PublicationCreating an Impactful Slide PresentationWriting a Good Clinical Research PaperMaking Sense of Reporting GuidelinesSubmitting a Paper for Publication—A Guide to SuccessKnowledge Translation 101—Maximizing ImpactGlossaryIndex