Clinical Proteomics

Methods and Protocols

Häftad, Engelska, 2022

Av Fernando J. Corrales, Alberto Paradela, Miguel Marcilla

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This detailed volume explores techniques in clinical proteomics, an emerging discipline aimed at deciphering the molecular mechanisms underlying the progression of diseases and at identifying new biomarkers and therapeutic targets to expand the physicians’ toolbox for precision medicine-based patient care.

Produktinformation

Utgivningsdatum2022-12-16
Mått178 x 254 x 16 mm
Vikt532 g
FormatHäftad
SpråkEngelska
SerieMethods in Molecular Biology
Antal sidor264
FörlagSpringer-Verlag New York Inc.
ISBN9781071619384

Tillhör följande kategorier

Medicin: allmänt inom Medicin
Biokemi inom Naturvetenskap och teknik

Bile Processing Protocol for Improved Proteomic Analysis.- MS-Based Extracellular Vesicles (EVs) Analysis: An Application to Helminth-Secreted EVs.- Proteomic Profiling of Cerebrospinal Fluid by 16-Plex TMT-Based Mass Spectrometry.- Data-Independent Acquisition Mass Spectrometry-Based Deep Proteome Analysis for Hydrophobic Proteins from Dried Blood Spots Enriched by Sodium Carbonate Precipitation.- Sample Processing for Metaproteomic Analysis of Human Gut Microbiota.- Mass Spectrometry-Based Analytical Strategy for Single Cell Proteomics.- Lysine Acetylation Stoichiometry Analysis at the Proteome Level.- Implementation of Clinical Phosphoproteomics and Proteomics for Personalized Medicine.- pH/Acetonitrile-Gradient-Reversed-Phase Fractionation of Enriched Hyper-Citrullinated Library in Combination with LC–MS/MS Analysis for Confident Identification of Citrullinated Peptides.- Purification of HLA Immunopeptidomes from Human Thymus.- Generation of HLA Allele-Specific Spectral Libraries to Identify and Quantify Immunopeptidomes by SWATH/DIA-MS.- Immunopeptidomic Analysis of the Phosphopeptidome Displayed by Hla Class I Molecules.- Development of a Standardized MRM Method for Quantification of One Carbon Metabolism Enzymes.- Molecular Histology Analysis of Cryopreserved Tissue Using Peptide/Protein MALDI-TOF Imaging Mass Spectrometry (MALDI-IMS).- The Human Protein Atlas and Antibody-Based Tissue Profiling in Clinical Proteomics.- Microbial Identification in the Clinical Microbiology Laboratory Using MALDI-TOF-MS.- Combining Electron Microscopy (EM) and Cross-Linking Mass Spectrometry (XL-MS) for Structural Characterization of Protein Complexes.- Accurate Prediction of Protein Sequences for Proteogenomics Data Integration.