Timothy G K Mant, Senior Medical Advisor of Quintiles, Guy's Drug Research Unit, London, UK Lionel D Lewis, Professor of Medicine, Pharmacology and Toxicology at Dartmouth Medical School and Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire, USA James M Ritter, Professor of Clinical Pharmacology at King's College London School of Medicine, Guy's, King's and St Thomas' Hospitals, London, UKAlbert Ferro, Reader in Clinical Pharmacology and Honorary Consultant Physician at King's College London School of Medicine, Guy's, King's and St Thomas' Hospitals, London, UK