Clinical Perspectives and Targeted Therapies in Apoptosis

Drug Discovery, Drug Delivery, and Disease Prevention

Häftad, Engelska, 2020

Av Rupinder K. Sodhi, Jitender Madan, Rupinder K Sodhi

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Clinical Perspectives and Targeted Therapies in Apoptosis: Drug Discovery, Drug Delivery, and Disease Prevention provides comprehensive coverage, from basic cell biology, to modern assessment techniques for apoptosis in all major disease areas. Chapters provide an introduction to the fundamentals of cell biology, biochemical mechanisms, and the pathophysiological consequences of apoptosis. In addition, the book covers the tools and techniques used to quantify apoptosis and the significance of apoptosis in drug discovery, drug delivery, and its applications in disease prevention. Finally, the book provides a comprehensive compilation of the apoptosis targeting drugs that recently underwent clinical trials.

This combination of fundamentals, along with applications in drug discovery, drug delivery, and clinical research make this book a useful resource for those in both academia and industry who are engaged in pharmaceutical, biomedical and biotechnology research.

Offers standard and innovative therapeutic approaches to modulate apoptosis in clinical interventions, such as cardiovascular diseases, immune disorders, cancer chemotherapy and neurological ailments
Covers cutting-edge laboratory techniques and traditional protocols to determine apoptosis, both in vitro and in vivo
Examines clinical study reports of new drug moieties that are explored for various pathological conditions associated with apoptosis

Produktinformation

Utgivningsdatum2020-10-15
Mått191 x 235 x 48 mm
Vikt1 000 g
FormatHäftad
SpråkEngelska
Antal sidor432
FörlagElsevier Science
ISBN9780128157626

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Farmakologi inom Medicin

Dr. Rupinder K Sodhi’s core areas of research cover different segments of neuropharmacology like cognition, dementia and Alzheimer’s disease. Central to her research activities involves evaluation of the potential of new chemical entities using advanced in vitro and in vivo tools and techniques. More over her expertise is in the field of neurodegenerative and neuropsychiatric disorders like Alzheimer, depression and also in diabetes and related complications such as neuropathic pain, nephropathy pain and inflammation aiming to deconvolute the novel target sites for drug discovery and development. Currently she is active in evaluating the therapeutic efficacy of controlled and targeted drug delivery systems such as nanomedicine in collaboration with pharmaceutics department. Dr. Jitender Madan is currently working as a faculty in Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research (NIPER), Hyderabad, Telangana, India at the position of Associate Professor. Dr. Jitender Madan has demonstrated an excellent level of expertise and dedication to both research and teaching. Dr. Jitender Madan completed his B.Pharmacy from Nagpur University, Nagpur (Maharashtra, India), M. Pharmacy (Pharmaceutical Biotechnology) from Department of Pharmaceutical Sciences, Dr. Hari Singh Gaur University, Saugar (Madhya Pradesh, India) and PhD (Pharmaceutical Sciences) from Institute of Pharmacy, Bundelkhand University, Jhansi (UttraPradesh, India). Later, he received postdoctoral position at Department of Biology, Georgia State University, Atlanta, GA, USA. A strong academic foundation allowed him to contribute significantly to the field of pharmaceutical sciences. Dr. Jitender Madan has supervised many M. Pharmacy (Pharmaceutics) and PhD (Pharmaceutical Sciences) students. Dr. Jitender Madan also contributed a lot in pharmaceutical product development. He has handled both Industry and Government funded projects. In addition, Dr. Jitender Madan has an impressive research portfolio. He has authored more than 130 peer-reviewed publications in international journals of repute, leading to an h-index of 35 and an i10-index of 88 with 3555 citations. He has also contributed approximately 50 book chapters in international books and holds many granted patents related to innovative processes and compositions aimed at enhancing therapeutic efficacy in topical, oral and intravaginal drug delivery. His scholarly work has earned him a place among the top 2% scientists worldwide in the field of Pharmacology and Pharmacy, according to global rankings compiled by Stanford University.

1. Introduction to Cell Biology2. Physiology of Cellular Demise3. Molecular Pathways of Apoptotic Cell Death4. Apoptosis: Warrior or Opponent5. Protocols in apoptosis identification and affirmation6. Modulating apoptosis in cancer 7. Cardiovascular diseases8. Recent approaches to target apoptosis in neurological disorders9. Autoimmune diseases and apoptosis: targets, challenges and innovations10. Clinical trials of promising apoptosis modulating drugs