This open access book presents the outcomes of the research developed within the PNRR T4Y PP 4.7.1 technology transfer project entitled “Open Phigital Platform (physical and digital) for user profiling and advanced, dynamic co-design of interventions on existing and new built environments.” The topics are of interest to the scientific community, as they concern the management of structural and environmental safety information related to cultural heritage. The first chapters in the book deepen the theoretical knowledge concerning cultural heritage analysis, proposing advanced models for damage assessment on structures and their surrounding environments. These models also incorporate uncertainties related to material properties and consider different environmental stressors under three projected climate scenarios for the years 2030, 2050, and 2085.This book also presents some final chapters having a more applicative slant, in which, also thanks to the help of some large-scale case studies, a digital platform will be proposed, to support all the meta-files relating to the security data collected, and this, together with the creation of a Living Lab (physical platform), will allow to propose a methodology for the transfer of digitalized data to different stakeholders: institutions, professionals and local communities.