To address the challenges posed by climate change, and to achieve the goals established in the 2015 Paris Agreement, nuclear power has been identified to have great potential to contribute to the 1.5°C climate change mitigation target. This topical conference on climate change and the role of nuclear power, the first of its kind, served as a unique forum for exchanging science-based information on the role of nuclear power in supporting the low carbon energy transformation and for conducting objective discussions on the opportunities and challenges of safe, secure and safeguarded nuclear technology development. The major themes of the conference covered energy and climate change policies, implications for the power sector, environmental perspectives and potential roles of existing, evolutionary and innovative nuclear power systems, including the integration of nuclear/renewable energy systems. In addition to nuclear power’s interim and long term contributions, some strategic and cross-cutting issues relating to public perception, regulations, markets and finance were also addressed. These proceedings provide a summary of the different plenary, technical and side event sessions as well as the full text of the speeches delivered in the opening, closing and high-level plenary sessions of the conference.