Classics in Total Synthesis III

K.C. Nicolaou holds joint appointments at The Scripps Research Institute, where he is the Chairman of the Department of Chemistry and holds the Darlene Shiley Chair in Chemistry and the Aline W. and L.S. Skaggs Professorship of Chemical Biology, and the University of California, San Diego, where he is Distinguished Professor of Chemistry. His impact on chemistry, biology and medicine flows from his research works in chemical synthesis and chemical biology described in numerous publications and patens. For his contributions to science and education, he was elected Fellow of the New York Academy of Sciences, Fellow of the American Academy of Arts and Sciences, Member of the National Academy of Sciences, USA, Member of the German Academy of Sciences Leopoldina, and Corresponding Member of the Academy of Athens, Greece. He is the recipient of many prizes, awards and honors. Jason S. Chen received his A.B. and A.M. degrees in Chemistry from Harvard University in 2001. After two years as a medicinal chemist at Enanta Pharmaceuticals, he began graduate studies at The Scripps Research Institute under the guidance of Professor K.C. Nicolaou. He received a National Defense Science and Engineering Graduate fellowship, and completed his Ph.D. studies in 2008. He currently is a post-doctoral fellow in Professor Nicolaou's laboratory.

• INTRODUCTION: THE ADVANCING FIELD OF TOTAL SYNTHESISTargetsStrategies and MethodsClassics in Total Synthesis III TETRODOTOXINIntroductionKishi's Retrosynthetic Analysis and StrategyKishi's Total SynthesisDu Bois' Retrosynthetic Analysis and StrategyDu Bois' Total SynthesisConclusion DISCODERMOLIDEIntroductionRetrosynthetic Analysis and StrategyTotal SynthesisConclusion AZASPIRACID-1IntroductionNicolaou's Retrosynthetic Analysis and StrategyNicolaou's Total SynthesisEvans' Retrosynthetic Analysis and StrategyEvans' Total SynthesisConclusion THIOSTREPTONIntroductionRetrosynthetic Analysis and StrategyTotal SynthesisConclusion PENTACYCLOANAMMOXIC ACID METHYL ESTERIntroductionFirst-Generation Retrosynthetic Analysis and StrategyFirst-Generation Total SynthesisSecond-Generation Retrosynthetic Analysis and StrategySecond-Generation Total SynthesisConclusion LITTORALISONE, OSELTAMIVIR (TAMIFLU®), AND HIRSUTELLONE BIntroductionIntroduction to LittoralisoneTotal Synthesis of LittoralisoneIntroduction to Oseltamivir (Tamiflu®)Total Synthesis of Oseltamivir (Tamiflu®)Introduction to Hirsutellone BTotal Synthesis of Hirsutellone BConclusion RUBICORDIFOLIN AND RUBIONCOLIN BIntroductionRetrosynthetic Analysis of RubicordifolinTotal Synthesis of RubicordifolinRetrosyntheticd Analysis of Rubioncolin BTotal Synthesis of Rubioncolin BConclusion CYANTHIWIGINS U AND FIntroductionPhillips' Retrosynthetic Analysis and StrategyPhillips' Total SynthesisStolz' Retrosynthetic Analysis and StrategyStoltz' Total SynthesisConclusion STEPHACIDIN BIntroductionMyers' Retrosynthetic Analysis and StrategyMeyers' Total SynthesisBaran's Retrosynthetic Analysis and StrategyBaran's Total SynthesisWilliams' Retrosynthetic Analysis and StrategyWilliams' Total SynthesisConclusion ABYSSOMICIN C AND ATROP-ABYSSOMICIN CIntroductionSorensen's Retrosynthetic Analysis and StrategySorensen's Total Synthesis of Abyssomicin CNicolaou's Retrosynthetic Analysis and StrategyNicolaou's Total Synthesis of Abyssomicin C and atrop-Abyssomicin CConclusion TETRACYCLINEIntroductionRetrosynthetic Analysis and StrategyTotal SynthesisConclusion BISANTHRAQUINONE NATURAL PRODUCTSIntroductionRetrosynthetic Analysis and Strategy Toward 2,2'-epi-Cytoskyrin A, Rugulosin, and RugulinTotal Synthesis of 2,2'-epi-Cytoskyrin A, Rugulosin, and RugulinRetrosynthetic Analysis and Strategy Toward Antibiotic BE-43472BTotal Synthesis of Antibiotic BE-43472BConclusion GARSUBELLIN AIntroductionSibasaki and Kanai's Retrosynthetic Analysis and StrategyShibasaki and Kanai's Total SynthesisDanishefsky's Retrosynthetic Analysis and StrategyDanishefsky's Total SynthesisConclusion WELWITINDOLINONE AIntroductionBaran's Retrosynthetic Analysis and StrategyBarans' Total SynthesisWood's Retrosynthetic Analysis and StrategyWood's Total SynthesisConclusion IEJIMALIDE BIntroductionRetrosynthetic Analysis and StrategyTotal SynthesisConclusion KEDARCIDIN CHROMOPHORE AND MADUROPEPTIN CHROMOPHOREIntroductionRetrosynthetic Analysis and Strategy for Kedarcidin ChromophoreTotal Synthesis of Kedarcidin ChromophoreRetrosynthetic Analysis and Strategy for Maduropeptin ChromophoreTotal Synthesis of Maduropeptin ChromophoreConclusion BIYOUYANAGIN AIntroductionRetrosynthetic Analysis and StrategyTotal SynthesisConclusion AZADIRACHTINIntroductionRetrosynthetic Analysis and StrategySynthesisConclusion RESVERATROL-DERIVED NATURAL PRODUCTSIntroductionSnyder's Retrosynthetic Analysis and Strategy for a Collection of Resveratrol-Derived Natural ProductsSnyder's Total Synthesis of a Collection of Resveratrol-Derived Natural ProductsNicolaou and Chen's Retrosynthetic Analysis and Strategy for Hopeahainol A and HopeanolNicolaou and Chen's Total Synthesis of Hopeahainol A and HopeanolConclusion CHLOROSULFOLIPID CYTOTOXINIntroductionRetrosynthetic Analysis and StrategyTotal SynthesisConclusion SPOROLIDE BIntroductionRetrosynthetic Analysis and StrategyTotal SynthesisConclusion 11,11'-DIDEOXYVERTICILLIN A AND CHAETOCINIntroductionRetrosynthetic Analysis and Strategy for 11,11'-Dideoxyverticillin ATotal Synthesis of 11,11'-Dideoxyverticillin ARetrosynthetic Analysis and Strategy for ChaetocinTotal Synthesis of ChaetocinConclusion VANNUSAL BIntroductionRetrosynthetic Analysis and StrategyTotal SynthesisConclusion HAPLOPHYTINEIntroductionFukuyama and Tokuyama's Retrosynthetic Analysis and StrategyFukuyama and Tokuyama's Total SynthesisNicolaou and Chen's Retrosynthetic Analysis and StrategyNicolaou and Chen's Total SynthesisConclusion PALAU'AMINEIntroductionRetrosynthetic Analysis and StrategyTotal SynthesisConclusion

"Classics in Total Synthesis III will surely itself become a classic in the literature on the state of the art of contemporary organic synthetic chemistry." (Angewandte Chemie, 2011)